Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of the alkaloid natural products (+)-plicane and (-)-obliquine, using polymer-supported reagents and scavengers
– Industrial & Engineering Chemistry Research
(2005)
44,
8588
(doi: 10.1021/ie048822i)
Heterogeneous or Homogeneous? A Case Study Involving Palladium-Containing Perovskites in the Suzuki Reaction
– Advanced Synthesis & Catalysis
(2005)
347,
647
(doi: 10.1002/adsc.200404331)
Stereoselective synthesis of (2R,3S,4S,5R)-trans-3,4-dihydroxy-5-(4-fluorophenoxymethyl)-2-(1-N-hydroxyureidyl-3-butyn-4-yl)tetrahydrofuran and (2R,3S,4S,5R)-trans-5-ethynyl-2(4-fluorophenoxymethyl)-3,4-O-isopropylidene tetrahydrofuran from mannose diacetonide
– Tetrahedron: Asymmetry
(2005)
16,
1135
(doi: 10.1016/j.tetasy.2005.01.046)
Stereoselective synthesis of chiral tetrahydrofurans with potent 5-LO inhibitory activity
– Tetrahedron: Asymmetry
(2005)
16,
1125
(doi: 10.1016/j.tetasy.2005.01.045)
Stereoselective syntheses of pharmaceutically relevant chiral tetrahydrofurans from (S)- and (R)-glyceraldehyde derivatives
– Tetrahedron Asymmetry
(2005)
16,
1113
(doi: 10.1016/j.tetasy.2005.01.044)
Towards the total synthesis of bengazole A
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229,
U515
Development of an enantioselective organocatalytic intramolecular cyclopropanation reaction.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229,
U366
New generation synthesis of the ef fragment of the spongistatins.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2005)
229,
U520
Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts.
– Chem Commun (Camb)
(2005)
2175
(doi: 10.1039/b418669a)
Stereoselective synthesis of (2S,7S)-7-(4-phenoxymethyl)2-(1-N-hydroxyureidyl-3-butyn-4-yl)oxepane:: a potential anti-asthmatic drug candidate
– Tetrahedron: Asymmetry
(2005)
16,
935
(doi: 10.1016/j.tetasy.2005.01.024)
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