Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
An efficient, asymmetric organocatalyst-mediated conjugate addition of nitroalkanes to unsaturated cyclic and acyclic ketones
– Org. Biomol. Chem.
(2006)
4,
2039
(doi: 10.1039/b601877g)
A highly enantioselective total synthesis of (+)- goniodiol
– Organic & Biomolecular Chemistry
(2006)
4,
1698
(doi: 10.1039/b602805e)
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
– Chemical Communications
(2006)
2566
(doi: 10.1039/b600382f)
Practical synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole, incorporating efficient protecting group removal by flow-reactor hydrogenolysis
– Synlett
(2006)
2006,
889
(doi: 10.1055/s-2006-939036)
Diastereoselective aldol reactions with butane-2,3-diacetal protected glyceraldehyde derivatives
– Organic and Biomolecular Chemistry
(2006)
4,
1471
(doi: 10.1039/b601888b)
Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds
– J Org Chem
(2006)
71,
2715
(doi: 10.1021/jo052514s)
Preparation of the Neolignan Natural Product Grossamide by a Continuous-Flow Process
– Synlett
(2006)
2006,
427
(doi: 10.1055/S-2006-926244)
A new strategy for oligosaccharide assembly exploiting cyclohexane-1,2-diacetal methodology: An efficient synthesis of a high mannose type nonasaccharide
– Chemistry A European Journal
(2006)
3,
431
(doi: 10.1002/chem.19970030315)
Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi-synthetic analogues
– FEMS Microbiology Letters
(2006)
120,
267
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