Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

8,9,10,10a-Tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazines: New Heterocyclic Frameworks Generated by an Ugi-Type Multicomponent Reaction

V Franckevicius, DA Longbottom, RM Turner, SV Ley

– Synthesis

(2006)

2006,

3215

(doi: 10.1055/s-2006-950219)

Hydrogenation of aromatic ketones, aldehydes, and epoxides with hydrogen and Pd(0)EnCat (TM) 30NP

SV Ley, AJP Stewart-Liddon, D Pears, RH Perni, K Treacher

– Beilstein journal of organic chemistry

(2006)

(doi: 10.1186/1860-5397-2-15)

A highly selective, organocatalytic route to chiral 1,2-oxazines from ketones

S Kumarn, DM Shaw, SV Ley

– Chemical Communications

(2006)

3211

(doi: 10.1039/b606338a)

Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools

SV Ley, IR Baxendale, DA Longbottom, RM Myers

(2006)

(doi: 10.1002/9780470085226.ch2)

Microwave‐Assisted Suzuki Coupling Reactions with an Encapsulated Palladium Catalyst for Batch and Continuous‐Flow Transformations

IR Baxendale, CM Griffiths-Jones, SV Ley, GK Tranmer

– Chemistry (Weinheim an der Bergstrasse, Germany)

(2006)

12,

4407

(doi: 10.1002/chem.200501400)

Microwave flow chemistry: The next evolutionary step in synthetic chemistry?

IR Baxendale, MR Pitts

– Chimica Oggi

(2006)

24,

(link to publication)

Effect of azadirachtin‐derived decalin (perhydronaphthalene) and dihydrofuranacetal (furo[2, 3‐fo]pyran) fragments on the feeding behaviour of Spodoptera littoralis

WM BLANEY, MSJ SIMMONDS, SV LEY, JC ANDERSON, SC SMITH, A WOOD

– Pesticide Science

(2006)

40,

169

(doi: 10.1002/ps.2780400212)

Progress towards avermectins and milbemycins

SV LEY

– Pest Management Science

(2006)

18,

153

(doi: 10.1002/ps.2780180210)

Targeting C-reactive protein for the treatment of cardiovascular disease

MB Pepys, GM Hirschfield, GA Tennent, JR Gallimore, MC Kahan, V Bellotti, PN Hawkins, RM Myers, MD Smith, A Polara, AJA Cobb, SV Ley, JA Aquilina, CV Robinson, I Sharif, GA Gray, CA Sabin, MC Jenvey, SE Kolstoe, D Thompson, SP Wood

– Nature

(2006)

440,

1217

(doi: 10.1038/nature04672)

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives.

G Zinzalla, L-G Milroy, SV Ley

– Organic & Biomolecular Chemistry

(2006)

1977

(doi: 10.1039/b603015g)

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