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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

[3+27] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor
CD Smith, IR Baxendale, S Lanners, JJ Hayward, SC Smith, SV Ley
– Org Biomol Chem
(2007)
5,
1559
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.
CD Smith, IR Baxendale, GK Tranmer, M Baumann, SC Smith, RA Lewthwaite, SV Ley
– Organic and Biomolecular Chemistry
(2007)
5,
1562
A Fascination with 1,2-Diacetals
SV Ley, A Polara
– The Journal of organic chemistry
(2007)
72,
5943
Continuous Flow Ligand-Free Heck Reactions Using Monolithic Pd [0] Nanoparticles
N Nikbin, M Ladlow, SV Ley
– Organic Process Research and Development
(2007)
11,
458
Influence of microwave irradiation on the reaction of MgO and Al2O3 slurries to form layered double hydroxide
SJ Mitchell, IR Baxendale, W Jones
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2007)
233,
205
Natural product synthesis: A stimulus for discovery
SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2007)
233,
Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin
SP Andrews, MM Tait, M Ball, SV Ley
– Organic and Biomolecular Chemistry
(2007)
5,
1427
Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator
KR Knudsen, J Holden, SV Ley, M Ladlow
– Advanced Synthesis and Catalysis
(2007)
349,
535
Chemical variation of natural-product-like scaffolds: Design, synthesis, and biological activity of fused bicyclic acetal derivatives
L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
– Angewandte Chemie (International ed. in English)
(2007)
46,
2493
Identification of a putative azadirachtin‐binding complex from Drosophila Kc167 cells
SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'
– Archives of Insect Biochemistry and Physiology
(2007)
64,
200
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk