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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.
SP Andrews, MM Tait, M Ball, SV Ley
– Organic & Biomolecular Chemistry
(2007)
5,
1427
Optimisation of conditions for O-benzyl and N-benzyloxycarbonyl protecting group removal using an automated flow hydrogenator
KR Knudsen, J Holden, SV Ley, M Ladlow
– Advanced Synthesis & Catalysis
(2007)
349,
535
Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives
L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
– Angew Chem Int Ed Engl
(2007)
46,
2493
Identification of a putative azadirachtin‐binding complex from Drosophila Kc167 cells
SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'
– Archives of Insect Biochemistry and Physiology
(2007)
64,
200
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow
– Journal of Combinatorial Chemistry
(2007)
9,
422
Total synthesis of rapamycin
ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley
– Angewandte Chemie International Edition
(2007)
46,
591
Total synthesis of thapsigargin, a potent SERCA pump inhibitor
M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley
– Organic letters
(2007)
9,
663
Total synthesis of rapamycin
ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley
– Angewandte Chemie International Edition
(2007)
46,
591
Use of the Temporary Connection in Organic Synthesis
LR Cox, SV Ley
(2007)
274
New avenues to efficient chemical synthesis
IR Baxendale, SV Ley
(2007)
151
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk