Professor Steve Ley CBE FRS FMedSci | Page 41 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

(S)- and (R)-5-Pyrrolidin-2-yl-1H-tetrazoles: Enantiomeric organocatalysts of broad utility in organic synthesis

DA Longbottom, V Franckevicius, SV Ley

– Chimia

(2007)

61,

247

(doi: 10.2533/chimia.2007.247)

Solid supported reagents in multi-step flow synthesis.

IR Baxendale, SV Ley

– Ernst Schering Foundation symposium proceedings

(2007)

2006/3,

151

(doi: 10.1007/2789_2007_033)

Chromatography-free Suzuki reactions using a polymer-assisted solution-phase (PASP) approach

E Vickerstaffe, AL Villard, M Ladlow, SV Ley

– Synlett

(2007)

2007,

1251

(doi: 10.1055/s-2007-977457)

A microcapillary flow disc reactor for organic synthesis

CH Hornung, MR Mackley, IR Baxendale, SV Ley

– Organic Process Research & Development

(2007)

11,

399

(doi: 10.1021/op700015f)

[3+2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor

CD Smith, IR Baxendale, S Lanners, JJ Hayward, SC Smith, SV Ley

– Organic & biomolecular chemistry

(2007)

5,

1559

(doi: 10.1039/b702995k)

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.

CD Smith, IR Baxendale, GK Tranmer, M Baumann, SC Smith, RA Lewthwaite, SV Ley

– Organic & Biomolecular Chemistry

(2007)

5,

1562

(doi: 10.1039/b703033a)

A Fascination with 1,2-Diacetals

SV Ley, A Polara

– The Journal of Organic Chemistry

(2007)

72,

5943

(doi: 10.1021/jo0703451)

Continuous flow ligand-free Heck reactions using monolithic Pd [0] nanoparticles

N Nikbin, M Ladlow, SV Ley

– Organic Process Research & Development

(2007)

11,

458

(doi: 10.1021/op7000436)

Natural product synthesis: A stimulus for discovery

SV Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2007)

233,

(link to publication)

Influence of microwave irradiation on the reaction of MgO and Al2O3 slurries to form layered double hydroxide

SJ Mitchell, IR Baxendale, W Jones

– ABSTR PAP AM CHEM S

(2007)

233,

205

(link to publication)