Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of Azadirachtin: A Long but Successful Journey
– Angewandte Chemie - International Edition
(2007)
46,
7629
(doi: 10.1002/anie.200703027)
Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.
– Ciba Foundation symposium
(2007)
154,
80
(doi: 10.1002/9780470514009.ch7)
A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines.
– Organic & biomolecular chemistry
(2007)
5,
2678
(doi: 10.1039/b708646f)
Natural Products as an Inspiration for the Discovery of New High‐Throughput Chemical Synthesis Tools
(2007)
2,
51
(doi: 10.1002/9780470085226.ch18)
ORGN 121-Toward the total synthesis of azadirachtin
– ABSTR PAP AM CHEM S
(2007)
234,
Chiral Glycolate Equivalents for the Asymmetric Synthesis of α-Hydroxycarbonyl Compounds
– Bulletin of the Chemical Society of Japan
(2007)
80,
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
– Organic & biomolecular chemistry
(2007)
5,
2758
(doi: 10.1039/b709043a)
Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub‐Nanomolar SERCA Inhibition
– Chemistry – A European Journal
(2007)
13,
5688
(doi: 10.1002/chem.200700302)
Total Synthesis of Potent Antifungal Marine Bisoxazole Natural Products Bengazoles A and B
– Chemistry – A European Journal
(2007)
13,
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical strategy and innovation: An academics perspective
– ChemMedChem
(2007)
2,
768
(doi: 10.1002/cmdc.200700008)
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