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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A relay route for the synthesis of azadirachtin
GE Veitch, E Beckmann, BJ Burke, A Boyer, C Ayats, SV Ley
– Angew Chem Int Ed Engl
(2007)
46,
7633
(doi: 10.1002/anie.200703028)
Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.
SV Ley
– Ciba Foundation Symposium
(2007)
154,
80
(doi: 10.1002/9780470514009.ch7)
Synthesis of azadirachtin: A long but successful journey
GE Veitch, E Beckmann, BJ Burke, A Boyer, SL Maslen, SV Ley
– Angew Chem Int Ed Engl
(2007)
46,
7629
(doi: 10.1002/anie.200703027)
A sequential enantioselective, organocatalytic route to chiral 1,2-oxazines and chiral pyridazines.
S Kumarn, AJ Oelke, DM Shaw, DA Longbottom, SV Ley
– Organic & Biomolecular Chemistry
(2007)
5,
2678
(doi: 10.1039/b708646f)
ORGN 121-Toward the total synthesis of azadirachtin
A Boyer, E Beckmann, GE Veitch, BJ Burke, SV Ley
– ABSTR PAP AM CHEM S
(2007)
234,
(link to publication)
Chiral glycolate equivalents for the asymmetric synthesis of alpha-hydroxycarbonyl compounds
SV Ley, TD Sheppard, RM Myers, MS Chorghade
– Bulletin of the Chemical Society of Japan
(2007)
80,
1451
(doi: 10.1246/bcsj.80.1451)
Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.
CJ Smith, FJ Iglesias-Sigüenza, IR Baxendale, SV Ley
– Organic & biomolecular chemistry
(2007)
5,
2758
(doi: 10.1039/b709043a)
Total synthesis of five thapsigargins: guaianolide natural products exhibiting sub-nanomolar SERCA inhibition.
SP Andrews, M Ball, F Wierschem, E Cleator, S Oliver, K Högenauer, O Simic, A Antonello, U Hünger, MD Smith, SV Ley
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2007)
13,
5688
(doi: 10.1002/chem.200700302)
Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B
JA Bull, EP Balskus, RAJ Horan, M Langner, SV Ley
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2007)
13,
5515
(doi: 10.1002/chem.200700033)
Pharmaceutical strategy and innovation: An academics perspective
IR Baxendale, JJ Hayward, SV Ley, GK Tranmer
– ChemMedChem
(2007)
2,
768
(doi: 10.1002/cmdc.200700008)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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