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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Azeotropic reflux chromatography: an efficient solution to a difficult separation in the scale-up synthesis of spongistatin 1.
M O'Brien, A Diéguez-Vázquez, D-S Hsu, H Kraus, Y Sumino, SV Ley
– Organic & biomolecular chemistry
(2008)
6,
1159
(doi: 10.1039/b719569a)
Synthesis of natural products from the Indian neem tree Azadirachta indica.
GE Veitch, A Pinto, A Boyer, E Beckmann, JC Anderson, SV Ley
– Organic Letters
(2008)
10,
569
(doi: 10.1021/ol7027898)
(S)-5-Pyrrolidin-2-yl-1H-tetrazole
V Aureggi, V Franckeviius, MO Kitching, SV Ley, DA Longbottom, AJ Oelke, G Sedelmeier, SE Denmark, RC Smith
– Organic Syntheses
(2008)
85,
72
(doi: 10.15227/orgsyn.085.0072)
(S)-5-pyrrolidin-2-yl-1H-tetrazole
V Aureggi, V Franckevičius, MO Kitching, SV Ley, DA Longbottom, AJ Oelke, G Sedelmeier
– Organic Syntheses
(2008)
85,
72
(doi: 10.15227/orgsyn.085.0072)
Microreactors in organic synthesis and catalysis
IR Baxendale, JJ Hayward, CD Smith, SV Ley, S Lanners
(2008)
Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin
ML Maddess, MN Tackett, SV Ley
– Prog Drug Res
(2008)
66,
13
(doi: 10.1007/978-3-7643-8595-8_2)
PtCl4‐Catalyzed Domino Synthesis of Fused Bicyclic Acetals
A Diéguez-Vázquez, CC Tzschucke, WY Lam, SV Ley
– Angewandte Chemie (International ed. in English)
(2007)
47,
209
(doi: 10.1002/anie.200704595)
Microwave Reactions Under Continuous Flow Conditions
IR Baxendale, JJ Hayward, SV Ley
– Comb Chem High Throughput Screen
(2007)
10,
802
(doi: 10.2174/138620707783220374)
A flow process for the multistep synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly
IR Baxendale, J Deeley, CM Griffiths-Jones, SV Ley, S Saaby, GK Tranmer
– Chemtracts
(2007)
20,
462
The development and application of supported reagents for multi-step organic synthesis
SV Ley, IR Baxendale
– SUPPORTED CATALYSTS AND THEIR APPLICATIONS
(2007)
9
(doi: 10.1039/9781847551962-00009)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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