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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones
V Wascholowski, KR Knudsen, CET Mitchell, SV Ley
– Chemistry - A European Journal
(2008)
14,
6155
(doi: 10.1002/chem.200800673)
A General Organocatalytic Enantioselective Malonate Addition to α,β‐Unsaturated Enones
V Wascholowski, KR Knudsen, CET Mitchell, SV Ley
– Chemistry - A European Journal
(2008)
14,
6155
(doi: 10.1002/chem.200800673)
Practical organocatalysis with (S)- and (r)-5-pyrrolidin-2-yl-1H-tetrazoles
DA Longbottom, V Franckevicius, S Kumarn, AJ Oelke, V Wascholowski, SV Ley
– Aldrichimica Acta
(2008)
41,
3
(link to publication)
A new focused microwave approach to the synthesis of amino-substituted pyrroloisoquinolines and pyrroloquinolines via a sequential multi-component coupling process
MD Hopkin, IR Baxendale, SV Ley
– Synthesis
(2008)
2008,
1688
(doi: 10.1055/s-2008-1067048)
The application of focused microwave irradiation coupled with freeze drying to investigate the reaction of MgO and Al 2 O 3 slurries in the formation of layered double hydroxides
S Mitchell, IR Baxendale, W Jones
– Green Chemistry
(2008)
10,
629
(doi: 10.1039/b801365a)
Design of a specific oxidant for phenols.
D Barton, SV Ley
– Novartis Foundation Symposia
(2008)
53,
53
(doi: 10.1002/9780470720349.ch5)
16th International Isotope Society (UK group) Symposium
G Aberg, FI Aigbirhio, E Alexakis, N Al-Maharik, M Almi, Y Ambacher, S Andersson, A Athlan, G Badman, SA Baldwin, M Baumann, IR Baxendale, NP Botting, RA Bragg, JA Brown, A Burton, N Bushby, K Cable, G Campbell, R Carr, M Carroll, L Chen, M Christlieb, P Davies, GJ Ellames, W Ellis, C Elmore, T Fryatt, N Geach, JR Harding, S Hartmann, S Harwood, JJ Hayward, PJF Henderson, RB Herbert, JR Heys, S Holzl, MD Hopkin, P Horn, T Ilyas, S Irvine, SD Jackson, J Jin, A Keats, AR Kennedy, WJ Kerr, MO Kitching, C Landreau, S Lanners, R Lawrence, KWM Lawrie, SV Ley, G Little, WJS Lockley, D Maier, C Manning, A Mcneill, DA Middleton, S Montgomery, JJ Morrison, L Mrzuak, J Newman, J Newsome, N Nikbin-Roudsari, GN Nilsson, MF Oldfield, SG Patching, DJ Procter, G Randall, AA Robertson, CS Rummel, D Rustidge, R Sherhod, N Shipley, CD Smith, CJ Smith, DI Smith, C Song, L Tamborini, I Waterhouse, A Watts, JL Werkheiser, G Williams, CL Willis, P Woodward, R Yan, G Young, Q Zhang
– Journal of Labelled Compounds and Radiopharmaceuticals
(2008)
51,
247
(doi: 10.1002/jlcr.1513)
FeCl3-Catalysed Cleavage of 1,2-Butanediacetal Protected Diols
CC Tzschucke, N Pradidphol, A Dieguez-Vazquez, B Kongkathip, N Kongkathip, SV Ley
– Synlett
(2008)
2008,
1293
(doi: 10.1055/s-2008-1072752)
A new synthesis of (-)-epipyriculol: a phytotoxic metabolite
A Leyva, FE Blum, SV Ley
– Tetrahedron
(2008)
64,
4711
(doi: 10.1016/j.tet.2008.01.115)
Protecting Groups: Effects on Reactivity, Glycosylation Stereoselectivity, and Coupling Efficiency
LG Green, SV Ley
(2008)
1-4,
427
(doi: 10.1002/9783527618255.ch17)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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