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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Highly diastereoselective desymmetrisation of cyclic meso-anhydrides and derivatisation for use in natural product synthesis
AC Evans, DA Longbottom, M Matsuoka, JE Davies, R Turner, V Franckevicius, SV Ley
– Organic & biomolecular chemistry
(2009)
7,
747
(doi: 10.1039/b813494d)
Stereoselective synthesis of inositol phosphates
SV LEY
– Pure and Applied Chemistry
(2009)
62,
2031
(doi: 10.1351/pac199062102031)
Tricarbonyliron lactone complexes in organic synthesis
SV LEY
– Pure and Applied Chemistry
(2009)
66,
1415
(doi: 10.1351/pac199466071415)
Development of methods suitable for natural product synthesis: The azadirachtin story
SV Ley
– Pure and Applied Chemistry
(2009)
77,
1115
(doi: 10.1351/pac200577071115)
Recent developments in natural product synthesis
SV LEY
– Pure and Applied Chemistry
(2009)
61,
401
(doi: 10.1351/pac198961030401)
Synthesis and chemistry of the insect antifeedant azadirachtin
SV LEY
– Pure and Applied Chemistry
(2009)
66,
2099
(doi: 10.1351/pac199466102099)
Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia
L-G Milroy, G Zinzalla, F Loiseau, Z Qian, G Prencipe, C Pepper, C Fegan, SV Ley
– Chemmedchem
(2008)
3,
1922
(doi: 10.1002/cmdc.200800265)
Methyliminodiacetic acid (MIDA) protected boronates: A new strategy for organic synthesis
CF Carter, SV Ley
– Chemtracts
(2008)
21,
457
The azadirachtin story.
GE Veitch, A Boyer, SV Ley
– Angewandte Chemie (International ed. in English)
(2008)
47,
9402
(doi: 10.1002/anie.200802675)
The synthesis of azadirachtin: A potent insect antifeedant
SV Ley, A Abad-Somovilla, JC Anderson, C Ayats, R Bänteli, E Beckmann, A Boyer, MG Brasca, A Brice, HB Broughton, BJ Burke, E Cleator, D Craig, AA Denholm, RM Denton, T Durand-Reville, LB Gobbi, M Göbel, BL Gray, RB Grossmann, CE Gutteridge, N Hahn, SL Harding, DC Jennens, L Jennens, PJ Lovell, HJ Lovell, ML de la Puente, HC Kolb, W-J Koot, SL Maslen, CF McCusker, A Mattes, AR Pape, A Pinto, D Santafianos, JS Scott, SC Smith, AQ Somers, CD Spilling, F Stelzer, PL Toogood, RM Turner, GE Veitch, A Wood, C Zumbrunn
– Chemistry
(2008)
14,
10683
(doi: 10.1002/chem.200801103)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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    About the University

    Research at Cambridge