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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Copper‐Catalyzed Arylations of Amines and Alcohols with Boron‐Based Arylating Reagents
AW Thomas, SV Ley
– MODERN ARYLATION METHODS
(2009)
121
(doi: 10.1002/9783527627325.ch4)
Total synthesis of the potent antifungal agents bengazole C and E
A Enriquez-Garcia, SV Ley
– ChemPlusChem
(2009)
74,
887
(doi: 10.1135/cccc2009016)
Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles
IR Baxendale, SV Ley, AC Mansfield, CD Smith
– Angewandte Chemie - International Edition
(2009)
48,
4017
(doi: 10.1002/anie.200900970)
An efficient and transition metal free protocol for the transfer hydrogenation of ketones as a continuous flow process
J Sedelmeier, SV Ley, IR Baxendale
– Green Chemistry
(2009)
11,
683
(doi: 10.1039/b821752a)
AuCl3‐Catalyzed Hydroalkoxylation of Conjugated Alkynoates: Synthesis of Five‐ and Six‐Membered Cyclic Acetals
A Dieguez-Vazquez, CC Tzschucke, J Crecente-Campo, S McGrath, SV Ley
– European Journal of Organic Chemistry
(2009)
2009,
1698
(doi: 10.1002/ejoc.200801221)
Synthesis and chemistry of the ionophore antibiotic tetronasin
SV Ley, JA Clase, DJ Mansfield, HMI Osborn
– Journal of Heterocyclic Chemistry
(2009)
33,
1533
(doi: 10.1002/jhet.5570330509)
A Base-Catalysed One-Pot Three-Component Coupling Reaction Leading to Nitrosubstituted Pyrroles
IR Baxendale, CD Buckle, SV Ley, L Tamborini
– Synthesis
(2009)
2009,
1485
(doi: 10.1055/s-0028-1087991)
Integrating Microwave‐Assisted Synthesis and Solid‐Supported Reagents
IR Baxendale, AL Lee, SV Ley
(2009)
133
(doi: 10.1002/9781444305548.ch6)
Total Synthesis of rapamycin
SV Ley, MN Tackett, ML Maddess, JC Anderson, PE Brennan, MW Cappi, JP Heer, C Helgen, M Kori, C Kouklovsky, SP Marsden, J Norman, DP Osborn, MA Palomero, JBJ Pavey, C Pinel, LA Robinson, J Schnaubelt, JS Scott, CD Spilling, H Watanabe, KE Wesson, MC Willis
– Chemistry
(2009)
15,
2874
(doi: 10.1002/chem.200801656)
Second-Generation Synthesis of Azadirachtin: A Concise Preparation of the Propargylic Mesylate Fragment
A Boyer, GE Veitch, E Beckmann, SV Ley
– Angew Chem Int Ed Engl
(2009)
48,
1317
(doi: 10.1002/anie.200805395)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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