Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A bifurcated pathway to thiazoles and imidazoles using a modular flow microreactor.

IR Baxendale, SV Ley, CD Smith, L Tamborini, AF Voica

Journal of Combinatorial Chemistry

(2008)

851

(doi: 10.1021/cc800070a)

Magnesium nitride as a convenient source of ammonia: Preparation of pyrroles

G Veitch, K Bridgwood, K Rands-Trevor, S Ley

Synlett

(2008)

2008

2597

(doi: 10.1055/s-0028-1083504)

Enantiopure 2-substituted glyceraldehyde derivatives by Aza-Claisen rearrangement or C-alkylation of enamines

KL Bridgwood, CC Tzschucke, M O'Brien, S Wittrock, JM Goodman, JE Davies, AWJ Logan, MRM Hüttl, SV Ley

Organic Letters

(2008)

4537

(doi: 10.1021/ol8018242)

Organic Chemistry in Microreactors

T Fukuyama, T Rahman, I Ryu, IR Baxendale, JJ Hayward, S Lanners, SV Ley, CD Smith, B Ahmed‐Omer, T Wirth, V Hessel, P Löb, H Löwe, K Koch, FPJT Rutjes, JCM van Hest

(2008)

(doi: 10.1002/9783527622856.ch4)

A tribute to Professor Ryoji!Noyori on the occasion of his 70^th birthday

JP Richmond, M Banwell, D Bellus, K Muniz, K Narasaka, Y Okamoto, J Okuda, M Schlosser, I Shinkai, K Tatsuta, G van Koten, X-Z You, VK Aggarwal, T Aida, H Alper, C Bai, K Bhattacharyya, H-U Blaser, B Pugin, F Spindler, JM Brown, SL Buchwald, ASC Chan, N Chatani, SE Denmark, F Diederich, MP Doyle, G Fu, A Fujishima, S Hanessian, S Hashimoto, M Hayashi, T Hiyama, P Hofmann, Z Hou, T Imamoto, K Izawa, E Jacobsen, T Katsuki, S Kim, S Kobayashi, K Komatsu, H Kumobayashi, EP Kuendig, E Lee, W Leitner, SV Ley, B Lipshutz, Y Lu, K Maruoka, S-I Murahashi, S Murai, KC Nicolaou, H Nishiyama, T Ohkuma, T Ohta, K Oshima, J Otera, A Pfaltz, MT Reetz, A Ricci, M Sawamoto, M Scalone, KB Sharpless, R Sheldon, V Snieckus, M Sodeoka, M Tokunaga, K Tomioka, Y Umezawa, Y Uozumi, C-H Wong, HNC Wong, Y Yamamoto, D Zhu

ADV SYNTH CATAL

(2008)

350

1925

The Use of Diethylaminosulfur Trifluoride (DAST) for Fluorination in a Continuous-Flow Microreactor

S Ley, M Baumann, I Baxendale

Synlett

(2008)

2008

2111

(doi: 10.1055/s-2008-1078026)

New tools for molecule makers: Emerging technologies

SV Ley

VDI Berichte

(2008)

Magnesium Nitride as a Convenient Source of Ammonia: Preparation of Primary Amides

GE Veitch, KL Bridgwood, SV Ley

Organic Letters

(2008)

3623

(doi: 10.1021/ol801398z)

Magnesium nitride as a convenient source of ammonia: preparation of dihydropyridines

KL Bridgwood, GE Veitch, SV Ley

Organic letters

(2008)

3627

(doi: 10.1021/ol801399w)

A general organocatalytic enantioselective malonate addition to α,β-unsaturated enones

V Wascholowski, KR Knudsen, CET Mitchell, SV Ley

Chemistry A European Journal

(2008)

6155

(doi: 10.1002/chem.200800673)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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