Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Recent developments in natural product synthesis
SV Ley
Pure and Applied Chemistry
(2009)
61
(doi: 10.1351/pac198961030401)
Propranol-therapy of subglottic haemangioma in an infant with fulminant respiratory distress
JG Eichhorn, W Springer, JP Schenk, H Becker, S Ley, M Eggert, HE Ulmer
CLINICAL RESEARCH IN CARDIOLOGY
(2009)
98
Synthesis and chemistry of the insectantifeedant azadirachtin
SV Ley
Pure and Applied Chemistry
(2009)
66
(doi: 10.1351/pac199466102099)
Stereoselective synthesis of inositol phosphates
SV Ley
Pure and Applied Chemistry
(2009)
62
(doi: 10.1351/pac199062102031)
Tricarbonyliron lactone complexes in organic synthesis
SV Ley
Pure and Applied Chemistry
(2009)
66
(doi: 10.1351/pac199466071415)
Development of methods suitable for natural product synthesis: The azadirachtin story
SV Ley
Pure and Applied Chemistry
(2009)
77
(doi: 10.1351/pac200577071115)
Natural‐Product‐Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B‐Cell Chronic Lymphocytic Leukaemia
L-G Milroy, G Zinzalla, F Loiseau, Z Qian, G Prencipe, C Pepper, C Fegan, SV Ley
ChemMedChem
(2008)
3
(doi: 10.1002/cmdc.200800265)
Methyliminodiacetic acid (MIDA) protected boronates: A new strategy for organic synthesis
CF Carter, SV Ley
Chemtracts
(2008)
21
The azadirachtin story
GE Veitch, A Boyer, SV Ley
Angewandte Chemie (International ed. in English)
(2008)
47
(doi: 10.1002/anie.200802675)
The synthesis of azadirachtin: A potent insect antifeedant
SV Ley, A Abad-Somovilla, JC Anderson, C Ayats, R Bänteli, E Beckmann, A Boyer, MG Brasca, A Brice, HB Broughton, BJ Burke, E Cleator, D Craig, AA Denholm, RM Denton, T Durand-Reville, LB Gobbi, M Göbel, BL Gray, RB Grossmann, CE Gutteridge, N Hahn, SL Harding, DC Jennens, L Jennens, PJ Lovell, HJ Lovell, ML de la Puente, HC Kolb, W-J Koot, SL Maslen, CF McCusker, A Mattes, AR Pape, A Pinto, D Santafianos, JS Scott, SC Smith, AQ Somers, CD Spilling, F Stelzer, PL Toogood, RM Turner, GE Veitch, A Wood, C Zumbrunn
Chemistry
(2008)
14
(doi: 10.1002/chem.200801103)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge