Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total synthesis of (-)-spirangien a and the corresponding methyl ester
– Chemtracts
(2009)
22,
173
Pd‐EnCatTM TPP30 as a Catalyst for the Generation of Highly Functionalized Aryl‐ and Alkenyl‐Substituted Acetylenes via Microwave‐Assisted Sonogashira Type Reactions
– European Journal of Organic Chemistry
(2009)
2009,
4412
(doi: 10.1002/ejoc.200900344)
Development of fluorination methods using continuous-flow microreactors
– Tetrahedron
(2009)
65,
6611
(doi: 10.1016/j.tet.2009.05.083)
Enantioselective synthesis of the lyngbouilloside macrolactone core
– Synlett
(2009)
2009,
2320
(doi: 10.1055/s-0029-1217707)
A microfluidic flow chemistry platform for organic synthesis: the Hofmann rearrangement
– Tetrahedron Letters
(2009)
50,
3287
(doi: 10.1016/j.tetlet.2009.02.059)
Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors
– ACS Chem Biol
(2009)
4,
503-25
(doi: 10.1021/cb900038e)
Cancer, Chemistry, and the Cell: Molecules that Interact with the Neurotensin Receptors
– ACS Chem Biol
(2009)
4,
503
(doi: 10.1021/cb900038e)
Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters
– Beilstein J Org Chem
(2009)
5,
23
(doi: 10.3762/bjoc.5.23)
Copper‐Catalyzed Arylations of Amines and Alcohols with Boron‐Based Arylating Reagents
– MODERN ARYLATION METHODS
(2009)
121
(doi: 10.1002/9783527627325.ch4)
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