skip to content
Home

Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues
MSJ SIMMONDS, WM BLANEY, SV LEY, JC ANDERSON, R BANTELI, AA DENHOLM, PCW GREEN, RB GROSSMAN, C GUTTERIDGE, L JENNENS, SC SMITH, PL TOOGOOD, A WOOD
– Entomologia Experimentalis et Applicata
(2011)
77,
69
(doi: 10.1111/j.1570-7458.1995.tb01987.x)
Insect antifeedants: a behavioural and electrophysiological investigation of natural and synthetically derived clerodane diterpenoids
WM BLANEY, MSJ SIMMONDS, SV LEY, PS JONES
– Entomologia Experimentalis et Applicata
(2011)
46,
267
(doi: 10.1111/j.1570-7458.1988.tb01121.x)
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae
MSJ SIMMONDS, WM BLANEY, SV LEY, JC ANDERSON, PL TOOGOOD
– Entomologia Experimentalis et Applicata
(2011)
55,
169
(doi: 10.1111/j.1570-7458.1990.tb01360.x)
Antifeedant effects of azadirachtin and structurally related compounds on lepidopterous larvae
WM BLANEY, MSJ SIMMONDS, SV LEY, JC ANDERSON, PL TOOGOOD
– Entomologia Experimentalis et Applicata
(2011)
55,
149
(doi: 10.1111/j.1570-7458.1990.tb01358.x)
Lesser-known enabling technologies for organic synthesis
M O'Brien, R Denton, SV Ley
– Synthesis
(2011)
1157
(doi: 10.1055/s-0030-1259979)
Lesser-Known Enabling Technologies for Organic Synthesis
M O'Brien, R Denton, SV Ley
– Synthesis
(2011)
2011,
1157
(doi: 10.1055/s-0030-1259979)
In-line monitoring for the accurate control of segmented flow processes
CF Carter, SV Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2011)
241,
(link to publication)
Oxidation reactions in segmented and continuous flow chemical processing using an N -(tert -Butyl)phenylsulfinimidoyl chloride monolith
H Lange, MJ Capener, AX Jones, CJ Smith, N Nikbin, IR Baxendale, SV Ley
– Synlett
(2011)
869
(doi: 10.1055/s-0030-1259923)
Oxidation Reactions in Segmented and Continuous Flow Chemical Processing Using an N-(tert-Butyl)phenylsulfinimidoyl Chloride Monolith
H Lange, MJ Capener, AX Jones, CJ Smith, N Nikbin, IR Baxendale, SV Ley
– Synlett
(2011)
2011,
869
(doi: 10.1055/s-0030-1259923)
Total synthesis of chloptosin: A dimeric cyclohexapeptide
AJ Oelke, F Antonietti, L Bertone, PB Cranwell, DJ France, RJM Goss, T Hofmann, S Knauer, SJ Moss, PC Skelton, RM Turner, G Wuitschik, SV Ley
– Chemistry – A European Journal
(2011)
17,
4183
(doi: 10.1002/chem.201003216)
  • <
  • 27 of 105
  • >

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

    Study at Cambridge

    About the University

    Research at Cambridge