Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring
– Organic Process Research & Development
(2011)
16,
1102
(doi: 10.1021/op200275d)
The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction
– Synlett
(2011)
2011,
2643
(doi: 10.1055/s-0031-1289291)
Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes
– Synlett
(2011)
2011,
2648
(doi: 10.1055/s-0031-1289292)
The continuous-flow synthesis of styrenes using ethylene in a palladium-catalysed heck cross-coupling reaction
– Synlett
(2011)
2011,
2643
(doi: 10.1055/s-0031-1289291)
Syngas-Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalysed Hydroformylation of Styrenes
– Synlett
(2011)
2011,
2648
(doi: 10.1055/s-0031-1289292)
The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact
– ChemSusChem
(2011)
5,
274
(doi: 10.1002/cssc.201100339)
Teflon AF-2400 mediated gas-liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration
– Organic & biomolecular chemistry
(2011)
9,
6903
(doi: 10.1039/c1ob06017a)
The flow synthesis of heterocycles for natural product and medicinal chemistry applications
– Molecular Diversity
(2011)
15,
613
(doi: 10.1007/s11030-010-9282-1)
Practical Synthetic Organic Chemistry
– Practical Synthetic Organic Chemistry: Reactions, Principles, and Techniques
(2011)
(doi: 10.1002/9781118093559)
Piperazic acid -containing natural products : Isolation, biological relevance and total synthesis
– Natural Product Reports
(2011)
28,
1445
(doi: 10.1039/c1np00041a)
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