Professor Steve Ley CBE FRS FMedSci | Page 24 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin

– Synthesis

(2012)

44,

635

(doi: 10.1055/s-0031-1289676)

A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles.

TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian

– ACS Med Chem Lett

(2012)

3,

177

(doi: 10.1021/ml200149g)

A total synthesis of millingtonine A.

J Wegner, SV Ley, A Kirschning, A-L Hansen, JM Garcia, IR Baxendale

– Organic Letters

(2012)

14,

696

(doi: 10.1021/ol203158p)

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1.

TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers

– Bioorganic & Medicinal Chemistry

(2012)

20,

1749

(doi: 10.1016/j.bmc.2012.01.010)

Discovery, design and synthesis of a novel series of non-peptidomimetic inhibitors of XIAP-caspase 9 interactions

DM Allwood, RM Myers, F Richards, A Bender, C Watts, SV Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2012)

243,

(link to publication)

Continuous stream processing: a prototype magnetic field induced flow mixer

P Koos, DL Browne, SV Ley

– Green Processing and Synthesis

(2012)

1,

11

(doi: 10.1515/greenps-2011-0501)

Twenty five years of azadirachtins

HE Hummel, DF Hein, W Kraus, SV Ley, ED Morgan, H Schmutterer

– MITTEILUNGEN DER DEUTSCHEN GESELLSCHAFT FUR ALLGEMEINE UND ANGEWANDTE ENTOMOLOGIE, BD 18

(2012)

18,

467

(link to publication)

Piecing together the puzzle: Understanding a mild, metal free reduction method for the large scale synthesis of hydrazines

DL Browne, IR Baxendale, SV Ley

– Tetrahedron

(2011)

67,

10296

(doi: 10.1016/j.tet.2011.09.146)

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors.

KA Roper, H Lange, A Polyzos, MB Berry, IR Baxendale, SV Ley

– Beilstein Journal of Organic Chemistry

(2011)

7,

1648

(doi: 10.3762/bjoc.7.194)

Piecing together the puzzle: understanding a mild, metal free reduction method for the large scale synthesis of hydrazines

DL Browne, IR Baxendale, SV Ley

– Tetrahedron

(2011)

67,

10296

(doi: 10.1016/j.tet.2011.09.146)