Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Asymmetric homogeneous hydrogenation in flow using a tube-in-tube reactor
– Advanced Synthesis and Catalysis
(2012)
354,
1805
(doi: 10.1002/adsc.201200073)
Rotamers or Diastereomers? An Overlooked NMR Solution
– Journal of Organic Chemistry
(2012)
77,
5198
(doi: 10.1021/jo300734r)
Continuous-flow processing of gaseous ammonia using a Teflon AF-2400 tube-in-tube reactor: Synthesis of thioureas and in-line titrations
– Synlett
(2012)
23,
1402
(doi: 10.1055/s-0031-1290963)
A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid
– Organic Process Research & Development
(2012)
16,
798
(doi: 10.1021/op300084z)
Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.
– Organic and Biomolecular Chemistry
(2012)
10,
5774
(doi: 10.1039/c2ob25407g)
The Lab of the Future The importance of remote monitoring and control
– Chimica Oggi/Chemistry Today
(2012)
30,
24
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1
– Bioorganic and Medicinal Chemistry
(2012)
20,
1749
(doi: 10.1016/j.bmc.2012.01.010)
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
– Proceedings of the National Academy of Sciences of the United States of America
(2012)
109,
E869
(doi: 10.1073/pnas.1115623109)
Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands
– Synthesis
(2012)
44,
635
(doi: 10.1055/s-0031-1289676)
Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands
– Synthesis
(2012)
2012,
635
(doi: 10.1055/s-0031-1289676)
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