Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of (-)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods

A Fernández, ZG Levine, M Baumann, S Sulzer-Mossé, C Sparr, S Schläger, A Metzger, IR Baxendale, SV Ley

– Synlett

(2013)

23,

514

(doi: 10.1055/s-0032-1318109)

A Continuous Flow Solution to Achieving Efficient Aerobic Anti-Markovnikov Wacker Oxidation

SL Bourne, SV Ley

– Advanced Synthesis and Catalysis

(2013)

342,

A prototype device for evaporation in batch and flow chemical processes

BJ Deadman, C Battilocchio, E Sliwinski, SV Ley

– Green Chemistry

(2013)

15,

2050

(doi: 10.1039/c3gc40967h)

Flow chemistry synthesis of zolpidem, alpidem and other GABAA agonists and their biological evaluation through the use of in-line frontal affinity chromatography

L Guetzoyan, N Nikbin, IR Baxendale, SV Ley

– Chem. Sci.

(2013)

764

(doi: 10.1039/c2sc21850j)