Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Continuous Cold without Cryogenic Consumables: Development of a Convenient Laboratory Tool for Low‐Temperature Flow Processes

DL Browne, BH Harji, SV Ley

Chemical Engineering & Technology

(2013)

959

(doi: 10.1002/ceat.201200581)

Synthesis of spongistatin 2 employing a new route to the EF fragment

H Kraus, A Français, M O'Brien, J Frost, A Diéguez-Vázquez, A Polara, N Baricordi, R Horan, D-S Hsu, T Tsunoda, SV Ley

Chemical Science

(2013)

1989

(doi: 10.1039/c3sc50304f)

The integration of flow reactors into synthetic organic chemistry

IR Baxendale

Journal of Chemical Technology and Biotechnology

(2013)

519

(doi: 10.1002/jctb.4012)

Synthesis of (-)-hennoxazole A: Integrating batch and flow chemistry methods

A Fernández, ZG Levine, M Baumann, S Sulzer-Mossé, C Sparr, S Schläger, A Metzger, IR Baxendale, SV Ley

Synlett

(2013)

514

(doi: 10.1055/s-0032-1318109)

Flow chemistry synthesis of zolpidem, alpidem and other GABA A agonists and their biological evaluation through the use of in-line frontal affinity chromatography

L Guetzoyan, N Nikbin, IR Baxendale, SV Ley

Chem. Sci.

(2013)

764

(doi: 10.1039/c2sc21850j)