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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Flow-based, cerium oxide enhanced, low-level palladium sonogashira and heck coupling reactions by perovskite catalysts
C Battilocchio, BN Bhawal, R Chorghade, BJ Deadman, JM Hawkins, SV Ley
– Israel Journal of Chemistry
(2013)
54,
371
(doi: 10.1002/ijch.201300049)
Continuous Flow-Processing of Organometallic Reagents Using an Advanced Peristaltic Pumping System and the Telescoped Flow Synthesis of (E/Z)‑Tamoxifen
PRD Murray, DL Browne, JC Pastre, C Butters, D Guthrie, SV Ley
– Organic Process Research & Development
(2013)
17,
1192
(doi: 10.1021/op4001548)
Flow chemistry syntheses of natural products.
JC Pastre, DL Browne, SV Ley
– Chemical Society Reviews
(2013)
42,
8849
(doi: 10.1039/c3cs60246j)
The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow.
KA Roper, MB Berry, SV Ley
– Beilstein J Org Chem
(2013)
9,
1781
(doi: 10.3762/bjoc.9.207)
Scaling up of continuous flow processes with gases using a tube-in-tube reactor: Inline titrations and fanetizole synthesis with ammonia
JC Pastre, DL Browne, M O'Brien, SV Ley
– Organic Process Research and Development
(2013)
17,
1183
(doi: 10.1021/op400152r)
The rapid generation of isothiocyanates in flow
M Baumann, IR Baxendale
– Beilstein J Org Chem
(2013)
9,
1613
(doi: 10.3762/bjoc.9.184)
Fragment-based hit identification: thinking in 3D
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, T Chapman, M Drysdale, IH Gilbert, S Hoelder, A Jordan, SV Ley, A Merritt, D Miller, ME Swarbrick, PG Wyatt
– Drug Discovery Today
(2013)
18,
1221
(doi: 10.1016/j.drudis.2013.07.011)
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research
IR Baxendale, S Cheung, MO Kitching, SV Ley, JW Shearman
– Bioorganic and Medicinal Chemistry
(2013)
21,
4378
(doi: 10.1016/j.bmc.2013.04.075)
A Continuous Flow Solution to Achieving Efficient Aerobic Anti‐Markovnikov Wacker Oxidation
SL Bourne, SV Ley
– Advanced Synthesis and Catalysis
(2013)
355,
1905
(doi: 10.1002/adsc.201300278)
Camera-enabled techniques for organic synthesis
SV Ley, RJ Ingham, M O'Brien, DL Browne
– Beilstein journal of organic chemistry
(2013)
9,
1051
(doi: 10.3762/bjoc.9.118)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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