Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

A Systems Approach towards an Intelligent and Self‐Controlling Platform for Integrated Continuous Reaction Sequences

RJ Ingham, C Battilocchio, DE Fitzpatrick, E Sliwinski, JM Hawkins, SV Ley

Angew Chem Int Ed Engl

(2014)

54

144

(doi: 10.1002/anie.201409356)

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

JA Newby, DW Blaylock, PM Witt, JC Pastre, MK Zacharova, SV Ley, DL Browne

Organic Process Research and Development

(2014)

18

1211

(doi: 10.1021/op500213j)

Reconfiguration of a continuous flow platform for extended operation: Application to a cryogenic fluorine-directed ortho-lithiation reaction

JA Newby, DW Blaylock, PM Witt, RM Turner, PL Heider, BH Harji, DL Browne, SV Ley

Organic Process Research & Development

(2014)

18

1221

(doi: 10.1021/op500221s)

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube‐in‐Tube Gas‐Liquid Microreactors

U Gross, P Koos, M O'Brien, A Polyzos, SV Ley

European Journal of Organic Chemistry

(2014)

2014

6418

(doi: 10.1002/ejoc.201402804)

Regioselective Preparation of Saturated Spirocyclic and Ring-Expanded Fused Pyrazoles

RR Merchant, DM Allwood, DC Blakemore, SV Ley

J Org Chem

(2014)

79

8800

(doi: 10.1021/jo501624t)

Flow Chemistry Meets Advanced Functional Materials

RM Myers, DE Fitzpatrick, RM Turner, SV Ley

Chemistry

(2014)

20

12348

(doi: 10.1002/chem.201402801)

Expedient Preparation of Nazlinine and a Small Library of Indole Alkaloids Using Flow Electrochemistry as an Enabling Technology

MA Kabeshov, B Musio, PRD Murray, DL Browne, SV Ley

Organic letters

(2014)

16

4618

(doi: 10.1021/ol502201d)

Process Intensification for the Continuous Flow Hydrogenation of Ethyl Nicotinate

T Ouchi, C Battilocchio, JM Hawkins, SV Ley

Organic Process Research and Development

(2014)

18

1560

(doi: 10.1021/op500208j)

Synthesis of riboflavines, quinoxalinones and benzodiazepines through chemoselective flow based hydrogenations.

M Baumann, IR Baxendale, CH Hornung, SV Ley, MV Rojo, KA Roper

Molecules (Basel, Switzerland)

(2014)

19

9736

(doi: 10.3390/molecules19079736)

Synthesis and Use of a Trifluoromethylated Azomethine Ylide Precursor: Ethyl 1-Benzyl-trans-5- (trifluoromethyl)pyrrolidine-3-carboxylate

DM Allwood, DL Browne, SV Ley

Organic Syntheses

(2014)

91

162

(doi: 10.15277/orgsyn.091.0162)