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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Development of a web-based platform for studying lithiation reactions in silico.
MA Kabeshov, É Sliwiński, DE Fitzpatrick, B Musio, JA Newby, WDW Blaylock, SV Ley
– Chemical communications (Cambridge, England)
(2015)
51,
7172
(doi: 10.1039/c5cc00782h)
Transition Metal Catalysis in Aerobic Alcohol Oxidation Foreword
SV Ley
(2015)
28,
VII
(link to publication)
Development of a flow method for the hydroboration/oxidation of olefins.
JA Souto, RA Stockman, SV Ley
– Organic & biomolecular chemistry
(2015)
13,
3871
(doi: 10.1039/c5ob00170f)
Total syntheses of natural products containing spirocarbocycles.
LK Smith, IR Baxendale
– Organic & Biomolecular Chemistry
(2015)
13,
9907
(doi: 10.1039/c5ob01524c)
A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions
MV Rojo, L Guetzoyan, IR Baxendale
– Organic & Biomolecular Chemistry
(2015)
13,
1768
(doi: 10.1039/c4ob02376e)
Back pressure regulation of slurry-forming reactions in continuous flow
BJ Deadman, DL Browne, IR Baxendale, SV Ley
– Chemical Engineering & Technology
(2014)
38,
259
(doi: 10.1002/ceat.201400445)
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20-21, 2014 Continuous Manufacturing Symposium
IR Baxendale, RD Braatz, BK Hodnett, KF Jensen, MD Johnson, P Sharratt, J-P Sherlock, AJ Florence
– J Pharm Sci
(2014)
104,
781
(doi: 10.1002/jps.24252)
Total Syntheses of Linear Polythiazole/Oxazole Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B
ZE Wilson, S Fenner, SV Ley
– Angewandte Chemie International Edition
(2014)
54,
1284
(doi: 10.1002/anie.201410063)
Sustainable Synthesis of Thioimidazoles via Carbohydrate-Based Multicomponent Reactions
M Baumann, IR Baxendale
– Organic letters
(2014)
16,
6076
(doi: 10.1021/ol502845h)
Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds
DN Tran, C Battilocchio, S-B Lou, JM Hawkins, SV Ley
– Chem Sci
(2014)
6,
1120
(doi: 10.1039/c4sc03072a)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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    About the University

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