Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Dynamic flow synthesis of porous organic cages.

ME Briggs, AG Slater, N Lunt, S Jiang, MA Little, RL Greenaway, T Hasell, C Battilocchio, SV Ley, AI Cooper

Chem Commun (Camb)

(2015)

51

17390

(doi: 10.1039/c5cc07447a)

An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins

S Ley, A Brahma, B Musio, U Ismayilova, N Nikbin, S Kamptmann, P Siegert, G Jeromin, M Pohl

Synlett

(2015)

27

262

(doi: 10.1055/s-0035-1560644)

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride

H Asadi-Saghandi, A Sheikhi, R Sotudeh-Gharebagh

ACS Sustainable Chemistry & Engineering

(2015)

3

2640

(doi: 10.1021/acssuschemeng.5b00392)

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

IR Baxendale

Chemical Engineering and Technology

(2015)

38

1713

(doi: 10.1002/ceat.201500255)

The Use of Gases in Flow Synthesis

CJ Mallia, IR Baxendale

Organic Process Research & Development

(2015)

20

327

(doi: 10.1021/acs.oprd.5b00222)

Foreword

SV Ley

(2015)

xiii

(doi: 10.1016/B978-0-12-417205-0.00040-7)

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation.

JR Frost, CM Pearson, TN Snaddon, RA Booth, RM Turner, J Gold, DM Shaw, MJ Gaunt, SV Ley

Chemistry

(2015)

21

13261

(doi: 10.1002/chem.201501877)

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

M Baumann, IR Baxendale

Beilstein Journal of Organic Chemistry

(2015)

11

1194

(doi: 10.3762/bjoc.11.134)

Machine-Assisted Organic Synthesis

SV Ley, DE Fitzpatrick, RM Myers, C Battilocchio, RJ Ingham

Angewandte Chemie (International ed. in English)

(2015)

54

10122

(doi: 10.1002/anie.201501618)

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

D De Lucia, OM Lucio, B Musio, A Bender, M Listing, S Dennhardt, A Koeberle, U Garscha, R Rizzo, S Manfredini, O Werz, SV Ley

European journal of medicinal chemistry

(2015)

101

573

(doi: 10.1016/j.ejmech.2015.07.011)