Professor Steve Ley CBE FRS FMedSci | Page 12 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Dynamic flow synthesis of porous organic cages.

ME Briggs, AG Slater, N Lunt, S Jiang, MA Little, RL Greenaway, T Hasell, C Battilocchio, SV Ley, AI Cooper

– Chemical Communications

(2015)

51,

17390

(doi: 10.1039/c5cc07447a)

An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins

A Brahma, B Musio, U Ismayilova, N Nikbin, SB Kamptmann, P Siegert, GE Jeromin, SV Ley, M Pohl

– Synlett

(2015)

27,

262

(doi: 10.1055/s-0035-1560644)

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride

C Schotten, D Plaza, S Manzini, SP Nolan, SV Ley, DL Browne, A Lapkin

– ACS Sustainable Chemistry & Engineering

(2015)

3,

2640

(doi: 10.1021/acssuschemeng.5b00392)

A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component

IR Baxendale

– Chemical Engineering & Technology

(2015)

38,

1713

(doi: 10.1002/ceat.201500255)

The Use of Gases in Flow Synthesis

CJ Mallia, IR Baxendale

– Organic Process Research & Development

(2015)

20,

327

(doi: 10.1021/acs.oprd.5b00222)

Foreword

SV Ley

(2015)

xiii

(doi: 10.1016/B978-0-12-417205-0.00040-7)

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation.

JR Frost, CM Pearson, TN Snaddon, RA Booth, RM Turner, J Gold, DM Shaw, MJ Gaunt, SV Ley

– Chemistry – A European Journal

(2015)

21,

13261

(doi: 10.1002/chem.201501877)

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.

M Baumann, IR Baxendale

– Beilstein journal of organic chemistry

(2015)

11,

1194

(doi: 10.3762/bjoc.11.134)

Machine‐Assisted Organic Synthesis

SV Ley, DE Fitzpatrick, RM Myers, C Battilocchio, RJ Ingham

– Angewandte Chemie - International Edition

(2015)

54,

10122

(doi: 10.1002/anie.201501618)

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

D De Lucia, OM Lucio, B Musio, A Bender, M Listing, S Dennhardt, A Koeberle, U Garscha, R Rizzo, S Manfredini, O Werz, SV Ley

– European Journal of Medicinal Chemistry

(2015)

103,

573

(doi: 10.1016/j.ejmech.2015.07.011)