Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Preparation of phenylselenoimines from phenols using diphenylseleninic anhydride and hexamethyldisilazane
– Journal of the Chemical Society, Chemical Communications
(1977)
147
(doi: 10.1039/c39770000147)
Reaction of tetracycline hydrochloride with N-chlorosuccinimide: X-ray crystal structure of the major product
– Journal of the Chemical Society, Chemical Communications
(1977)
790
(doi: 10.1039/c39770000790)
ELECTROPHILIC FLUORINATION OF ACTIVATED OLEFINS - SYNTHESIS OF 6-FLUORO-CORTICOSTEROIDS
– NOUVEAU JOURNAL DE CHIMIE-NEW JOURNAL OF CHEMISTRY
(1977)
1,
315
EXPERIMENTS ON SYNTHESIS OF TETRACYCLINE .15. OXIDATION OF PHENOLS AND RING-A MODEL PHENOLS TO O-HYDROXY-DIENONES WITH BENZENE-SELENINIC ANHYDRIDE
– J CHEM SOC PERK T 1
(1977)
567
(doi: 10.1039/p19770000567)
Oxidation of phenols to ortho-quinones using diphenylseleninic anhydride
– Chemical Communications
(1976)
985
(doi: 10.1039/c39760000985)
The stability of NN-dialkylthiohydroxylamines
– Chemical Communications
(1975)
855
(doi: 10.1039/c39750000855)
Aryne chemistry. Part XXXIII. Reactions of tetrahalogenobenzynes with methoxyarenes and the photolysis and thermolysis of some of the products
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1974)
2681
(doi: 10.1039/p19740002681)
Rearrangement reactions of bicyclic systems. Part II. Rearrangements of 1-dimethylamino-5,6,7,8-tetrahalogeno-1,4-dihydro-1,4-ethenonaphthalene derivatives and the analogous 5,6,7,8-tetrafluoro-1,4-dihydro-N-methyl-1,4-iminonaphthalene in aqueous solutions
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1974)
2698
(doi: 10.1039/P19740002698)
REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .4. ACID-CATALYZED REARRANGEMENTS OF 5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-1-METHOXY-3,9-DIMETHYL-1,4-ETHENONAPHTHALENE (1-METHOXY-3,5-DIMETHYLTETRAFLUOROBENZOBARRELENE)
– Journal of the Chemical Society, Perkin Transactions 1
(1974)
2711
(doi: 10.1039/p19740002711)
Aryne chemistry. Part XXXV. Reactions of arynes with 1-amino-cycloalkenes and hydrolyses of the adducts
– Journal of the Chemical Society Perkin Transactions 1
(1974)
2693
(doi: 10.1039/p19740002693)
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