Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Conversion of thiocarbonyl compounds into their corresponding oxo derivatives using benzeneseleninic anhydride
– Chemical Communications
(1978)
393
(doi: 10.1039/C39780000393)
Oxidation of alcohols using benzeneseleninic anhydride
– Chemical Communications
(1978)
952
(doi: 10.1039/c39780000952)
The formation of unusual sultones during the rearrangement reactions of bicyclic ketones
– Tetrahedron Letters
(1978)
19,
3937
Oxidation of aldehyde hydrazones, hydrazo compounds, and hydroxylamines with benzeneseleninic anhydride
– Chemical Communications
(1978)
276
(doi: 10.1039/c39780000276)
Dehydrogenation of steroidal ketones using benzeneseleninic anhydride
– Chemical Communications
(1978)
130
(doi: 10.1039/c39780000130)
Regeneration of ketones from hydrazones, oximes, and semicarbazones by benzeneseleninic anhydride
– Journal of the Chemical Society, Chemical Communications
(1977)
445
(doi: 10.1039/C39770000445)
Mechanism of the thermal decomposition of tetra-aryltellurium species
– Chemical Communications
(1977)
266
(doi: 10.1039/C39770000266)
Removal of 1,3-dithiolan protecting groups by benzeneseleninic anhydride
– Chemical Communications
(1977)
751
(doi: 10.1039/c39770000751)
Formation of lactones from dienes via iron carbonyl complexes
– Chemical Communications
(1977)
581
(doi: 10.1039/C39770000581)
X -Ray evidence for partial bonding between sulphur or selenium and oxygen in thio- and seleno-imines
– Journal of the Chemical Society, Chemical Communications
(1977)
325
(doi: 10.1039/c39770000325)
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