Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Welcome to Reaction Chemistry & Engineering
Reaction Chemistry & Engineering
(2016)
1
8
(doi: 10.1039/c6re90001a)
Flow enabled peptide synthesis
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines
Synlett
(2015)
27
159
(doi: 10.1055/s-0035-1560391)
Controlled Flow Precipitation as a Valuable Tool for Synthesis
Organic Process Research & Development
(2015)
20
371
(doi: 10.1021/acs.oprd.5b00331)
Synthesis of 1,3,6-Trisubstituted Azulenes
The Journal of organic chemistry
(2015)
80
11513
(doi: 10.1021/acs.joc.5b02271)
A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis
Organic Process Research & Development
(2015)
20
386
(doi: 10.1021/acs.oprd.5b00313)
Synthesis of a Precursor to Sacubitril Using Enabling Technologies.
Org Lett
(2015)
17
5436
(doi: 10.1021/acs.orglett.5b02806)
Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade
The Journal of organic chemistry
(2015)
80
10806
(doi: 10.1021/acs.joc.5b01982)
Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583]
European Journal of Medicinal Chemistry
(2015)
103
223
(doi: 10.1016/j.ejmech.2015.08.050)
Modeling mesoscale reactors for the production of fine chemicals
Chemical Engineering Journal
(2015)
278
353
(doi: 10.1016/j.cej.2014.12.030)
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