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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Continuous-Flow Synthesis of 2 H -Azirines and Their Diastereoselective Transformation to Aziridines
M Baumann, IR Baxendale
– Synlett
(2015)
27,
159
(doi: 10.1055/s-0035-1560391)
Controlled Flow Precipitation as a Valuable Tool for Synthesis
P Filipponi, A Gioiello, IR Baxendale
– Organic Process Research & Development
(2015)
20,
371
(doi: 10.1021/acs.oprd.5b00331)
Synthesis of 1,3,6-Trisubstituted Azulenes
TO Leino, M Baumann, J Yli-Kauhaluoma, IR Baxendale, EAA Wallén
– The Journal of organic chemistry
(2015)
80,
11513
(doi: 10.1021/acs.joc.5b02271)
A Novel Internet-Based Reaction Monitoring, Control and Autonomous Self-Optimization Platform for Chemical Synthesis
DE Fitzpatrick, C Battilocchio, SV Ley
– Organic Process Research and Development
(2015)
20,
386
(doi: 10.1021/acs.oprd.5b00313)
Batch and Flow Synthesis of Pyrrolo[1,2-a]-quinolines via an Allene-Based Reaction Cascade
M Baumann, IR Baxendale
– The Journal of organic chemistry
(2015)
80,
10806
(doi: 10.1021/acs.joc.5b01982)
Synthesis of a Precursor to Sacubitril Using Enabling Technologies
S-H Lau, SL Bourne, B Martin, B Schenkel, G Penn, SV Ley
– Organic letters
(2015)
17,
5436
(doi: 10.1021/acs.orglett.5b02806)
Corrigendum to “Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors” [Eur. J. Med. Chem. 101 (2015) 573–583] (European Journal of Medicinal Chemistry (2015) 101 (573–583), (S0223523415301434), (10.1016/j.ejmech.2015.07.011))
D de Lucia, OM Lucio, B Musio, A Bender, M Listing, S Dennhardt, A Koeberle, U Garscha, R Rizzo, S Manfredini, O Werz, SV Ley
– European Journal of Medicinal Chemistry
(2015)
103,
223
(doi: 10.1016/j.ejmech.2015.08.050)
Modeling mesoscale reactors for the production of fine chemicals
PM Witt, S Somasi, I Khan, DW Blaylock, JA Newby, SV Ley
– Chemical Engineering Journal
(2015)
278,
353
(doi: 10.1016/j.cej.2014.12.030)
Dynamic flow synthesis of porous organic cages.
ME Briggs, AG Slater, N Lunt, S Jiang, MA Little, RL Greenaway, T Hasell, C Battilocchio, SV Ley, AI Cooper
– Chemical Communications
(2015)
51,
17390
(doi: 10.1039/c5cc07447a)
An orthogonal biocatalytic approach for the safe generation and use of HCN in a multistep continuous preparation of chiral O-acetylcyanohydrins
A Brahma, B Musio, U Ismayilova, N Nikbin, SB Kamptmann, P Siegert, GE Jeromin, SV Ley, M Pohl
– Synlett
(2015)
27,
262
(doi: 10.1055/s-0035-1560644)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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