Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
Journal of the Chemical Society Chemical Communications
(1986)
344
(doi: 10.1039/c39860000344)
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1986)
1
46
(doi: 10.1039/c39860000046)
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
Journal of the Chemical Society Perkin Transactions 1
(1986)
303
(doi: 10.1039/p19860000303)
Ultrasonic formation and reactions of sodium phenylselenide
Tetrahedron
(1986)
42
5363
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
Journal of Organometallic Chemistry
(1985)
285
C17
(doi: 10.1016/0022-328x(85)87394-0)
ORGANOSELENIUM-MEDIATED CYCLISATION REACTIONS IN ORGANIC SYNTHESIS.
Chemistry and Industry London
(1985)
101
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
CHEM IND-LONDON
(1985)
101
Preparation and reactions of 2-benzenesulphonyltetrahydropyran
Tetrahedron Letters
(1985)
26
535
SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND
Tetrahedron Letters
(1985)
26
5837
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
Tetrahedron
(1985)
41
4765
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