Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Azadirachtin: structural requirements for reducing growth and increasing mortality in lepidopterous larvae.
Entomologia Experimentalis et Applicata.
(1990)
55
169
(doi: 10.1007/bf00352578)
Alkenylcyclic sulphites as novel precursors for the preparation of π-allyltricarbonyliron lactone complexes
Synlett
(1990)
1990
224
(doi: 10.1055/s-1990-21044)
Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
Tetrahedron
(1990)
46
4995
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
Aldrichimica Acta
(1990)
23
13
Neo-clerodane insect antifeedants from Scutellaria galericulata
Phytochemistry
(1990)
29
1793
(doi: 10.1016/0031-9422(90)85018-B)
INSECT ANTIFEEDANTS
CHEM BRIT
(1990)
26
31
ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES
Tetrahedron
(1990)
46
4063
SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS
CIBA FOUNDATION SYMPOSIA
(1990)
154
80
Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
Tetrahedron Letters
(1990)
31
5525
Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).
Tetrahedron Letters
(1990)
31
5521
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