Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .2. CHARACTERIZATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF SOME NOVEL REARRANGED AZADIRACHTINS
Tetrahedron
(1991)
47
9231
Chemistry of insect antifeedants from azadirachta indica (Part 9): oxidative reactions of azadirachtin derivatives leading to C8-C14 bond cleavage.
Tetrahedron Letters
(1991)
32
6183
(doi: 10.1016/0040-4039(91)80784-4)
Chemistry of insect antifeedants from Azadirachta indica (Part 10): synthesis of a highly functionalised decalin fragment of azadirachtin.
Tetrahedron Letters
(1991)
32
6187
(doi: 10.1016/0040-4039(91)80785-5)
THE TOTAL SYNTHESIS OF AGGLOMERIN-A AND (+/-)-CAROLINIC ACID - A GENERAL-METHOD FOR THE PREPARATION OF 3-ACYL TETRONIC ACIDS VIA DIRECT ACYLATION OF O-METHYL 3-STANNYL TETRONATES
Tetrahedron
(1991)
47
8285
Chemistry of insect antifeedants from azadirachta indica (part 8): Synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies.
Tetrahedron
(1991)
47
6813
Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes.
Tetrahedron Letters
(1991)
32
2651
Use of phenylsulphonylmethano ethers in synthesis: A new versatile route to substituted cyclic ethers
Synlett
(1991)
1991
415
(doi: 10.1055/s-1991-20747)
Chapter 7 The Champagne Route to Avermectins and Milbemycins
(1991)
3
237
Microbial Oxidation in Synthesis: Preparation of Novel 3-Substitutedcis-Cyclohexa-3,5-diene-1,2-diol Derivatives from (1S,2S)-3-Bromocyclohexa-3,5-diene-1,2-diol
Synlett
(1991)
1991
741
(doi: 10.1055/s-1991-34764)
SYNTHESIS OF INSECT ANTIFEEDANTS
PESTICIDE CHEMISTRY : ADVANCES IN INTERNATIONAL RESEARCH, DEVELOPMENT, AND LEGISLATION
(1991)
97
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