Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The chemistry of azadirachtin

SV Ley, AA Denholm, A Wood

Natural Product Reports

(1993)

10

109

(doi: 10.1039/np9931000109)

Selective Acylation and Alkylation Reactions of Diols Using Dibutyltin Dimethoxide

G-J Boons*, G Castle, J Clase, P Grice, S Ley, C Pinel

Synlett

(1993)

1993

913

(doi: 10.1055/s-1993-22650)

Total synthesis of the spiroketal macrolide (+) milbemycin α1

SV Ley, A Madin, NJT Monck

Tetrahedron Letters

(1993)

34

7479

(doi: 10.1016/S0040-4039(00)60158-2)

Microwave promoted hydrolysis of esters absorbed on alumina: A new deprotection method for pivaloyl groups

S Ley*, D Mynett

Synlett

(1993)

1993

793

(doi: 10.1055/s-1993-22612)

Synthesis of 4-Substituted Imidazoles via 4-Metallo Imidazole Intermediates

R Turner*, S Ley, S Lindell

Synlett

(1993)

1993

748

(doi: 10.1055/s-1993-22594)

Dispiroketals in synthesis (part 4): Enantioselective desymmetrization of glycerol using a c2-symmetric disubstituted bis-dihydropyran.

B Geert-Jan, DA Entwistle, SV Ley, M Woods

Tetrahedron Letters

(1993)

34

5649

(doi: 10.1016/S0040-4039(00)73906-2)

UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA

PA Paranagama, H Lovell, AA Denholm, SV Ley, JD Connolly, RHC Strang

Journal of Insect Physiology

(1993)

39

935

(doi: 10.1016/0022-1910(93)90003-a)

Dispiroketals in synthesis (Part 5): A new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors

G-J Boons, P Grice, R Leslie, SV Ley, LL Yeung

Tetrahedron Letters

(1993)

34

8523

(doi: 10.1016/S0040-4039(00)61375-8)

Chemistry of insect antifeedants from Azadirachta Indica (Part 15):1 Degradation studies of Azadirachtin leading to C8C14 bond cleavage.

SV Ley, PJ Lovell, AMZ Slawin, SC Smith, DJ Williams, A Wood

Tetrahedron

(1993)

49

1675

(doi: 10.1016/s0040-4020(01)80354-9)

Some Alkylation and Reductive Amination Studies of b-Ketomacrolides as Potential Metal Speciation Materials

S V. Ley, S V. Kelkar

Heterocycles

(1993)

35

263

(doi: 10.3987/com-92-s12)