Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates
Tetrahedron
(1994)
50
7157
Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates
Tetrahedron Letters
(1994)
35
769
DISPIROKETALS IN SYNTHESIS .15. SIMULTANEOUS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTION OF GLYCEROL BY REACTION WITH C-2 SYMMETRICAL (4S,4'S)-DIMETHYL-BIS-DIHYDROPYRAN
Synthesis
(1994)
1994
1275
(doi: 10.1055/s-1994-25680)
TETRAPROPYLAMMONIUM PERRUTHENATE, PR4N+RUO4-, TPAP - A CATALYTIC OXIDANT FOR ORGANIC-SYNTHESIS
Synthesis
(1994)
1994
639
(doi: 10.1055/s-1994-25538)
DISPIROKETALS IN SYNTHESIS .17. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSIDE, D-GALACTOPYRANOSIDE AND D-MANNOPYRANOSIDE SUBSTRATES
Tetrahedron Asymmetry
(1994)
5
2609
Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates
Tetrahedron Letters
(1994)
35
773
DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN
Tetrahedron Asymmetry
(1994)
5
553
(doi: 10.1016/0957-4166(94)80016-2)
Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes
Journal of the Chemical Society Chemical Communications
(1994)
1931
(doi: 10.1039/c39940001931)
"Connectivist" approach to organic structure determination Lsd-program assisted Nmr analysis of the insect antifeedant Azadirachtin
Tetrahedron
(1994)
50
12267
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .17. SYNTHESIS OF MODEL COMPOUNDS OF AZADIRACHTIN - UNUSUAL EFFECT OF REMOTE SUBSTITUENTS ON THE COURSE OF THE OXIDATIVE RING CONTRACTION REACTION
Tetrahedron
(1994)
50
11553
- ‹ previous
- Page 80
