Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Tritiated dihydroazadirachtin binging to Schistocerca gregaria testes and Spodoptera Sf9 cells suggests a similar cellular mechanism of action for azadirachtin
AJ Mordue, AJ Nisbet, L Jennens, SV Ley, W Mordue
AZADIRACHTA INDICA A. JUSS.
(1999)
Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion
V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González
HYPERTENSION
(1999)
33
Prevalence of systemic hypertension in morbid obesity.: Polysomnographic study.
M Fernández, V Rebollar, J Oseguera, A Orea, M Valencia, C Keirns, J Dorantes, M Reséndiz, M Rosales, R Campos, S Ley, X Gómez, J González-B, G García
HYPERTENSION
(1999)
33
Myocardial ischemia induced by obstructive sleep apnea in the hypertensive morbidly obese without known heart disease demonstrated by (SPECT) Tc 99m sestamibl preliminary report
A Orea, V Rebollar, M Valencia, M Fernández, M Rosales, A Castaño, C Keirns, J Dorantes, J Sepulveda, S Ley, G Garcia, J Oseguera, O González, J González
HYPERTENSION
(1999)
33
Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives
SV Ley, DJ Dixon
Chemtracts
(1999)
12
Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR
SK Latypov, JM Seco, E Quinoa, R Riguera, E Fernandez-Megia, SV Ley
Chemtracts
(1999)
12
Chemical synthesis of the N-glycans of gp63, the major surface glycoprotein from Leishmania mexicana amazonensis
A Düffels, SV Ley
Journal of the Chemical Society, Perkin Transactions 1
(1999)
(doi: 10.1039/a809798d)
Chemistry of insect antifeedants from Azadirachta indica (Part 22): Functionalisation of the decalin fragment of azadirachtin via a Claisen rearrangement reaction
SV Ley*, CE Gutteridge, AR Pape, CD Spilling, C Zumbrunn
Synlett
(1999)
1999
(doi: 10.1055/s-1999-2802)
Assembly of dendritic glycoclusters from monomeric mannose building blocks
P Langer, SJ Ince, SV Ley
Journal of the Chemical Society Perkin Transactions 1
(1998)
(doi: 10.1039/a807621i)
Total synthesis of the protein phosphatase inhibitor okadaic acid
SV Ley, AC Humphries, H Eick, R Downham, AR Ross, RJ Boyce, JBJ Pavey, J Pietruszka
Journal of the Chemical Society, Perkin Transactions 1
(1998)
(doi: 10.1039/a807957i)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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