Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction
Chemtracts
(2000)
13
592
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
Reductive decomplexation of pi-allyltricarbonyliron lactone complexes: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
J CHEM SOC PERK T 1
(2000)
211
(doi: 10.1039/a907630a)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
Chemtracts
(2000)
13
66
Clean and efficient synthesis of azo dyes using polymer-supported reagents
Green Chemistry
(2000)
2
43
(doi: 10.1039/b000816h)
Asymmetric molybdenum-catalyzed allylic substitution.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants
Journal of the Chemical Society, Perkin Transactions 1
(2000)
3645
(doi: 10.1039/b003129l)
Membership changes - Reply
CHEMISTRY IN BRITAIN
(2000)
36
23
Untitled - Comment
CHEMISTRY IN BRITAIN
(2000)
36
3
1,2-Diacetals in synthesis: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei
Chemistry
(1999)
6
172
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