Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito
M Arai, O Billker, HR Morris, M Panico, M Delcroix, D Dixon, SV Ley, RE Sinden
Mol Biochem Parasitol
(2001)
116
(doi: 10.1016/S0166-6851(01)00299-7)
Butane-2,3-diacetal-desymmetrized glycolic acid - A new building block for the stereoselective synthesis of enantiopure alpha-hydroxy acids
E Díez, DJ Dixon, SV Ley
Angewandte Chemie International Edition
(2001)
40
(doi: 10.1002/1521-3773(20010803)40:15<2906::AID-ANIE2906>3.0.CO;2-5)
Development and Application of a Carbonyl-13C-Enriched Backbone Amide Linker for Solid-Phase Reaction Monitoring
C Jamieson, MS Congreve, PR Hewitt, JJ Scicinski, SV Ley
J Comb Chem
(2001)
3
(doi: 10.1021/cc010012w)
Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.
JJ Scicinski, MS Congreve, C Jamieson, SV Ley, ES Newman, VM Vinader, RA Carr
Journal of combinatorial chemistry
(2001)
3
(doi: 10.1021/cc0100114)
New catalysts for olefin metathesis
M Scholl, S Ding, CW Lee, RH Grubbs, PE Brennan, SV Ley, AK Chatterjee, JP Morgan
Chemtracts
(2001)
14
Approaches to the total synthesis of antascomicin A.
SV Ley, DEA Brittain, JS Barlow, MD Smith, K Yasuda
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221
Studies toward the total synthesis of rapamycin.
SV Ley, PE Brennan
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221
A new phase-switch method for application in organic synthesis programs employing immobilization through metal-chelated tagging
SV Ley, A Massi, F Rodríguez, DC Horwell, RA Lewthwaite, MC Pritchard, AM Reid
Angewandte Chemie International Edition
(2001)
40
(doi: 10.1002/1521-3773(20010316)40:6<1053::AID-ANIE10530>3.0.CO;2-D)
A New Phase‐Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal‐Chelated Tagging
SV Ley, A Massi, F Rodríguez, DC Horwell, RA Lewthwaite, MC Pritchard, AM Reid
Angewandte Chemie (International ed. in English)
(2001)
40
(doi: 10.1002/1521-3773(20010316)40:6<1053::aid-anie10530>3.0.co;2-d)
A polymer-supported thionating reagent
SV Ley, AG Leach, RI Storer
J CHEM SOC PERK T 1
(2001)
(doi: 10.1039/b008814p)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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