Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.
B Musio, E Gala, SV Ley
ACS Sustainable Chemistry & Engineering
(2018)
6
(doi: 10.1021/acssuschemeng.7b04012)
A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross‐Coupling Reactions
A Greb, J Poh, S Greed, C Battilocchio, P Pasau, DC Blakemore, SV Ley
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201710445)
Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives.
LNS Crespin, A Greb, DC Blakemore, SV Ley
The Journal of organic chemistry
(2017)
82
(doi: 10.1021/acs.joc.7b02146)
A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters
F Lima, UK Sharma, L Grunenberg, D Saha, S Johannsen, J Sedelmeier, EV Van der Eycken, SV Ley
Angewandte Chemie - International Edition
(2017)
56
(doi: 10.1002/anie.201709690)
A New Versatile Route to Unstable Diazo Compounds via Oxadiazolines and Use In Aryl-Alkyl Cross-Coupling Reactions
A Greb, J-S Poh, S Greed, C Battilocchio, P Pasau, DC Blakemore, SV Ley
Angewandte Chemie International Edition
(2017)
56
(doi: 10.1002/anie.201710445)
Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3‑Bromoisoxazolines
C Battilocchio, F Bosica, SM Rowe, B Lacerda Abreu, E Godineau, M Lehmann, SV Ley
Organic Process Research and Development
(2017)
21
(doi: 10.1021/acs.oprd.7b00229)
Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines
R labes, DG Calderon, C Battilocchio, C Mateos, GR Cumming, O de Frutos, JA Rincon, SV Ley
Synlett
(2017)
28
(doi: 10.1055/s-0036-1589096)
Chemoselective Continuous Ru-Catalyzed Hydrogen-transfer Oppenauer-type Oxidation of Secondary Alcohols
R Labes, C Battilocchio, C Mateos, GR Cumming, O de Frutos, JA Rincón, K Binder, SV Ley
Organic Process Research & Development
(2017)
21
(doi: 10.1021/acs.oprd.7b00190)
Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids.
C Bomio-Confaglia, Ley, Kabeshov, Battilocchio, lau, lit, ehlert
Chem Sci
(2017)
8
(doi: 10.1039/c7sc02264f)
Flow synthesis of cyclobutanones $\textit{via}$ [2 + 2] cycloaddition of keteneiminium salts and ethylene gas
C Battilocchio, G Iannucci, S Wang, E Godineau, A Krieger, A De Mesmaeker, SV Ley
Reaction Chemistry & Engineering
(2017)
2
(doi: 10.1039/c7re00020k)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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