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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

UNSATURATED HETEROCYCLIC-SYSTEMS .97. THERMAL-ISOMERIZATION OF HOMOAZOCINES
GD EWING, SV LEY, LA PAQUETTE
– Journal of the American Chemical Society
(2002)
100,
2909
(doi: 10.1021/ja00477a066)
Luminescence dynamics and 13C NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
KD MATTHEWS, SA BAILEYFOLKES, IA KAHWA, GL MCPHERSON, CA OMAHONEY, SV LEY, DJ WILLIAMS, CJ GROOMBRIDGE, CA OCONNOR
– The Journal of Physical Chemistry
(2002)
96,
7021
(doi: 10.1021/j100196a033)
An Efficient Synthesis of (-)-Triquinacene-2-carboxylic Acid
LA PAQUETTE, SV LEY, WB FARNHAM
– Journal of the American Chemical Society
(2002)
96,
312
(doi: 10.1021/ja00808a081)
Immobilization of thallium by tandem oxidation/reduction-complexation of thallium(I/III)
IA KAHWA, D MILLER, M MITCHEL, FR FRONCZEK, RG GOODRICH, DJ WILLIAMS, CA OMAHONEY, AMZ SLAWIN, SV LEY, CJ GROOMBRIDGE
– Inorganic Chemistry
(2002)
31,
3963
(doi: 10.1021/ic00045a020)
Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction
LA PAQUETTE, SV LEY, MEISINGE.RH, RK RUSSELL, M OKU
– Journal of the American Chemical Society
(2002)
96,
5806
(doi: 10.1021/ja00825a019)
Alkali Metal Reduction Studies of cis- and trans-Bicyclo[6.1.0]nona-2,4,6-trienes in Liquid Ammonia. Evidence for the High Basicity of Monohomocyclooctatetraene Dianions
SV LEY, LA PAQUETTE
– Journal of the American Chemical Society
(2002)
96,
6670
(doi: 10.1021/ja00828a021)
A facile route to imidazol-4-yl anions and their reaction with carbonyl compounds
RM TURNER, SD LINDELL, SV LEY
– The Journal of Organic Chemistry
(2002)
56,
5739
(doi: 10.1021/jo00020a002)
TETRACYANOETHYLENE ADDITION TO IRON TRICARBONYL COMPLEXES OF SUBSTITUTED CYCLOOCTATETRAENES - REGIOSELECTIVITY CONSIDERATIONS DURING FORMATION OF 2,3,4,10-TETRAHAPTO ADDUCTS
LA PAQUETTE, SV LEY, S MAIORANA, DF SCHNEIDER, MJ BROADHURST, RA BOGGS
– Journal of the American Chemical Society
(2002)
97,
4658
(doi: 10.1021/ja00849a031)
Polyurea-encapsulated palladium(II) acetate: a robust and recyclable catalyst for use in conventional and supercritical media.
SV Ley, C Ramarao, RS Gordon, AB Holmes, AJ Morrison, IF McConvey, IM Shirley, SC Smith, MD Smith
– Chemical communications (Cambridge, England)
(2002)
2,
1134
(doi: 10.1039/b200677b)
Encapsulation of palladium in polyurea microcapsules
C Ramarao, SV Ley, SC Smith, IM Shirley, N DeAlmeida
– Chem Commun (Camb)
(2002)
10,
1132
(doi: 10.1039/b200674j)
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Research Group

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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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