Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of taurospongin A : a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
– Chemical communications (Cambridge, England)
(2002)
2,
1624
(doi: 10.1039/b204994p)
Total Synthesis of the Amaryllidaceae Alkaloid (+)‐Plicamine and Its Unnatural Enantiomer by Using Solid‐Supported Reagents and Scavengers in a Multistep Sequence of Reactions
– Angew Chem Int Ed Engl
(2002)
41,
2194
UNSATURATED HETEROCYCLIC-SYSTEMS .98. SYNTHESIS AND REDUCIBILITY OF HOMO-2-METHOXYAZOCINES AND THEIR BENZO-FUSED DERIVATIVES - EXAMINATION OF HETEROATOMIC INFLUENCES ON POSSIBLE GENERATION OF 9C-10-PI HOMOAROMATIC DIANIONS
– The Journal of Organic Chemistry
(2002)
43,
4712
(doi: 10.1021/jo00419a007)
The question of delocalization in "anchored" ions with potential trishomoaromatic character. 1. Reduction of tricyclo[5.4.1.04,12]dodeca-2,5,8,10-tetraene as a route to the 10.pi.11C dianion
– Journal of the American Chemical Society
(2002)
99,
4756
(doi: 10.1021/ja00456a037)
NITROGEN ANALOGS OF 1,6-METHANO[12]ANNULENE - EFFECT ON VALENCE TAUTOMERISM OF LOCUS OF AZA SUBSTITUTION
– The Journal of Organic Chemistry
(2002)
40,
902
(doi: 10.1021/jo00895a020)
Formation of Monohomocyclooctatetraene Dianions in Liquid Ammonia. Analysis of the Nucleophilic Reactivity of the Cyclononatrienyl Anions Generated Upon Solvent Protonation
– Journal of the American Chemical Society
(2002)
98,
8162
(doi: 10.1021/ja00441a046)
Thermal isomerization of homoazocines
– Journal of the American Chemical Society
(2002)
100,
2909
(doi: 10.1021/ja00477a066)
Synthesis and reducibility of homo-2-methoxyazocines and their benzo-fused derivatives. An examination of heteroatomic influences on the possible generation of 9C-10.pi. homoaromatic dianions
– The Journal of Organic Chemistry
(2002)
43,
4712
(doi: 10.1021/jo00419a007)
TOTAL SYNTHESIS OF THE IONOPHORE ANTIBIOTIC X-14547A (INDANOMYCIN)
– The Journal of Organic Chemistry
(2002)
49,
3503
(doi: 10.1021/jo00193a014)
Homotropylium-8-Sulfinate Complexes by SbF5-Promoted Ring Opening of 9-Thiabicyclo[4.2.1]nona-2,4,7-Triene and 9-Thiabarbaralane 9,9-Dioxides
– Journal of the American Chemical Society
(2002)
98,
152
(doi: 10.1021/ja00417a023)
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