Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-ProtectedGlycolic Acid
Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: [(2-propenoic acid, 3-iodo-, (2E)-)]
Organic Syntheses
(2003)
80
129
(doi: 10.15227/orgsyn.080.0129)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.
Chemical communications (Cambridge, England)
(2003)
678
Development of β-keto 1,3-dithianes as versatile intermediates for organic synthesis
Organic & Biomolecular Chemistry
(2003)
1
15
(doi: 10.1039/b208982c)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
Chemical Communications
(2003)
3
468
(doi: 10.1039/b210673f)
Use of π -allyltricarbonyliron lactone complexes in the synthesis of taurospongin A : a potent inhibitor of DNA polymerase β and HIV reverse transcriptase
Organic & biomolecular chemistry
(2003)
1
1664
(doi: 10.1039/b301676p)
Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors (vol 1, pg 2419, 2003)
ORGANIC & BIOMOLECULAR CHEMISTRY
(2003)
1
2807
(doi: 10.1039/b305713e)
Reductive decomplexation of pi-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols.
Organic and Biomolecular Chemistry
(2003)
1
3197
(doi: 10.1039/b306861g)
1,5-Asymmetric induction of chirality using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-functionalised carbonyl compounds
Organic and Biomolecular Chemistry
(2003)
1
3208
(doi: 10.1039/b306862e)
A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxy-pyrazino[1 ',2 ': 1,5]pyrrolo[2,3-b]indole-1,4-diones
Organic and Biomolecular Chemistry
(2003)
1
3492
(doi: 10.1039/b308288a)
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