Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Chemical Variation of Natural‐Product‐Like Scaffolds: Design, Synthesis, and Biological Activity of Fused Bicyclic Acetal Derivatives
L Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
Angewandte Chemie
(2007)
119
(doi: 10.1002/ange.200604688)
Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.
L-G Milroy, G Zinzalla, G Prencipe, P Michel, SV Ley, M Gunaratnam, M Beltran, S Neidle
Angew Chem Int Ed Engl
(2007)
46
(doi: 10.1002/anie.200604688)
Identification of a putative azadirachtin‐binding complex from Drosophila Kc167 cells
SL Robertson, W Ni, TS Dhadialla, AJ Nisbet, C McCusker, SV Ley, W Mordue, AJ Mordue 'Luntz'
Archives of insect biochemistry and physiology
(2007)
64
(doi: 10.1002/arch.20171)
Fully automated flow-through synthesis of secondary sulfonamides in a binary reactor system
CM Griffiths-Jones, MD Hopkin, D Jönsson, SV Ley, DJ Tapolczay, E Vickerstaffe, M Ladlow
ACS Combinatorial Science
(2007)
9
(doi: 10.1021/cc060152b)
Total synthesis of rapamycin
ML Maddess, MN Tackett, H Watanabe, PE Brennan, CD Spilling, JS Scott, DP Osborn, SV Ley
Angewandte Chemie International Edition
(2007)
46
(doi: 10.1002/anie.200604053)
Total synthesis of thapsigargin, a potent SERCA pump inhibitor
M Ball, SP Andrews, F Wierschem, E Cleator, MD Smith, SV Ley
Organic letters
(2007)
9
(doi: 10.1021/ol062947x)
Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography
JG Eichhorn, FR Long, S Hill, S Ley, M Gorenflo, R Arnold, H-U Kauczor, HE Ulmer, J Cheatham
CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96
Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT
JG Eichhorn, C Fink, R Krissak, HJ Ruediger, S Ley, R Arnold, M Khalil, H-U Kauczor, M Gorenflo, HE Ulmer
CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96
Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development
IR Baxendale, RM Myers, DA Longbottom, SV Ley
(2007)
New avenues to efficient chemical synthesis
IR Baxendale, SV Ley
(2007)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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