Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin

ML Maddess, MN Tackett, SV Ley

Progress in Drug Research

(2008)

66

13

(doi: 10.1007/978-3-7643-8595-8_2)

Microreactors in organic synthesis and catalysis

IR Baxendale, JJ Hayward, CD Smith, SV Ley, S Lanners

(2008)

PtCl₄-catalyzed domino synthesis of fused bicyclic acetals

A Diéguez-Vázquez, CC Tzschucke, WY Lam, SV Ley

Angew Chem Int Ed Engl

(2007)

47

209

(doi: 10.1002/anie.200704595)

Microwave reactions under continuous flow conditions

IR Baxendale, JJ Hayward, SV Ley

Comb Chem High Throughput Screen

(2007)

10

802

(doi: 10.2174/138620707783220374)

A flow process for the multistep synthesis of the alkaloid natural product oxomaritidine: A new paradigm for molecular assembly

IR Baxendale, J Deeley, CM Griffiths-Jones, SV Ley, S Saaby, GK Tranmer

Chemtracts

(2007)

20

462

The development and application of supported reagents for multi-step organic synthesis

DC Sherrington, AP Kybett, SV Ley, IR Baxendale

SUPPORTED CATALYSTS AND THEIR APPLICATIONS

(2007)

9

(doi: 10.1039/9781847551962-00009)

[MR-based tridirectional flow imaging. Acquisition and 3D analysis of flows in the thoracic aorta].

R Unterhinninghofen, S Ley, A Frydrychowicz, M Markl

Die Radiologie

(2007)

47

1012

(doi: 10.1007/s00117-007-1577-6)

A relay route for the synthesis of azadirachtin

GE Veitch, E Beckmann, BJ Burke, A Boyer, C Ayats, SV Ley

Angew Chem Int Ed Engl

(2007)

46

7633

(doi: 10.1002/anie.200703028)

Synthesis of Azadirachtin: A Long but Successful Journey

GE Veitch, E Beckmann, BJ Burke, A Boyer, SL Maslen, SV Ley

Angew Chem Int Ed Engl

(2007)

46

7629

(doi: 10.1002/anie.200703027)

Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.

SV Ley

Ciba Foundation symposium

(2007)

154

80

(doi: 10.1002/9780470514009.ch7)