Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Aryne chemistry. Part XXXV. Reactions of arynes with 1-aminocycloalkenes and hydrolyses of the adducts

H Heaney, SV Ley

J CHEM SOC PERK T 1

(1974)

2693

(doi: 10.1039/p19740002693)

Rearrangement reactions of bicyclic systems. Part III. acid-catalysed rearrangements of 1,4-dihydro-1-methoxy-1,4-ethenonaphthalene (1-methoxybenzobarrelene) and its 5,6,7,8-tetrahalogeno-derivatives

NJ Hales, H Heaney, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1974)

2702

(doi: 10.1039/P19740002702)

Rearrangement reactions of bicyclic systems. Part II. Rearrangements of 1-dimethylamino-5,6,7,8-tetrahalogeno-1,4-dihydro-1,4-ethenonaphthalene derivatives and the analogous 5,6,7,8-tetrafluoro-1,4-dihydro-n-methym,4-iminonaphthalene in aqueous solutions

H Heaney, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1974)

2698

(doi: 10.1039/p19740002698)

REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .4. ACID-CATALYZED REARRANGEMENTS OF 5,6,7,8-TETRAFLUORO-1,4-DIHYDRO-1-METHOXY-3,9-DIMETHYL-1,4-ETHENONAPHTHALENE (1-METHOXY-3,5-DIMETHYLTETRAFLUOROBENZOBARRELENE)

H Heaney, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1974)

2711

(doi: 10.1039/P19740002711)

Aryne chemistry. Part XXXIV. Reactions of NN -dimethylarylamines with tetrahalogenobenzynes

JPN Brewer, H Heaney, SV Ley, TJ Ward

J CHEM SOC PERK T 1

(1974)

2688

(doi: 10.1039/P19740002688)

ARYNE CHEMISTRY .33. REACTIONS OF TETRAHALOGENOBENZYNES WITH METHOXYARENES AND PHOTOLYSIS AND THERMOLYSIS OF SOME OF PRODUCTS

PC Buxton, NJ Hales, B Hankinson, H Heaney, SV Ley, RP Sharma

Journal of the Chemical Society Perkin Transactions 1

(1974)

2681

(doi: 10.1039/p19740002681)

N -alkylation of indole and pyrroles in dimethyl sulphoxide

H Heaney, SV Ley

J CHEM SOC PERK T 1

(1973)

499

(doi: 10.1039/p19730000499)

REARRANGEMENT REACTIONS OF BICYCLIC SYSTEMS .1. SYNTHESIS OF A MODEL COMPOUND RELATED TO FLAVOTHEBAONE TRIMETHYL ETHER - ABNORMAL ULTRAVIOLET-ABSORPTION SPECTRUM OF FLAVOTHEBAONE AND ITS TRIMETHYL ETHER

H Heaney, JH Hollinshead, GW Kirby, SV Ley, RP Sharma, KW Bentley

J CHEM SOC PERK T 1

(1973)

1840

(doi: 10.1039/p19730001840)

Mećhanistic dichotomy in cycloadditions to cyclooctatetraeneiron tricarbonyl. X-ray crystal structure analysis of the TCNE and CSI adducts

LA Paquette, SV Ley, MJ Broadhurst, D Truesdell, J Fayos, J Clardy

Tetrahedron Letters

(1973)

2943

(doi: 10.1016/s0040-4039(01)96288-4)

Thermal reactions of 1,4-bridged-1,2,3,4-tetrahydronaphthalene derivatives

H Heaney, SV Ley, AP Price, RP Sharma

Tetrahedron Letters

(1972)

3067

(doi: 10.1016/S0040-4039(01)85010-3)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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