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Yusuf Hamied Department of Chemistry

 

Professor Michele Vendruscolo

Professor of Biophysics

Our research

In the last 15 years our research has been focused on the development of methods of characterising the structure, dynamics and interactions of proteins in previously inaccessible states. These methods are based on the use of experimental data, in particular from nuclear magnetic resonance spectroscopy, as structural restraints in molecular dynamics simulations. Through this approach it is possible to obtain information about a variety of protein conformations, as for example those populated during the folding process, and about protein interactions in complex environments, including those generating aggregate species that are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

Application to neurodegenerative diseases

More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.

Watch Professor Vendruscolo discuss his research

Take a tour of the Una Finlay Laboratory in the Centre for Misfolding Diseases

Publications

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins.
FN Newby, A De Simone, M Yagi-Utsumi, X Salvatella, CM Dobson, M Vendruscolo
– Biochemistry
(2015)
54,
6876
(doi: 10.1021/acs.biochem.5b00670)
ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.
T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop
– Neuron
(2015)
88,
678
(doi: 10.1016/j.neuron.2015.10.030)
Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations.
P Kukic, A Kannan, MJJ Dijkstra, S Abeln, C Camilloni, M Vendruscolo
– PLoS Computational Biology
(2015)
11,
e1004435
(doi: 10.1371/journal.pcbi.1004435)
The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments
D Granata, F Baftizadeh, J Habchi, C Galvagnion, A De Simone, C Camilloni, A Laio, M Vendruscolo
– Scientific Reports
(2015)
5,
15449
(doi: 10.1038/srep15449)
ChemInform Abstract: Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates
MA Wright, FA Aprile, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– ChemInform
(2015)
46,
no
(doi: 10.1002/chin.201545294)
Particle-based simulations of steady-state mass transport at high Péclet numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
(2015)
(link to publication)
Particle-based simulations of steady-state mass transport at high Péclet numbers
T Müller, P Arosio, L Rajah, SIA Cohen, EV Yates, M Vendruscolo, CM Dobson, TPJ Knowles
(2015)
(doi: 10.48550/arxiv.1510.05126)
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity
EV Yates, T Müller, L Rajah, EJ De Genst, P Arosio, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles
– Nature chemistry
(2015)
7,
802
(doi: 10.1038/NCHEM.2344)
Structure and Dynamics of Intrinsically Disordered Proteins
B Fu, M Vendruscolo
– Advances in experimental medicine and biology
(2015)
870,
35
(doi: 10.1007/978-3-319-20164-1_2)
Druggability of Intrinsically Disordered Proteins
P Joshi, M Vendruscolo
– Adv Exp Med Biol
(2015)
870,
383
(doi: 10.1007/978-3-319-20164-1_13)
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Telephone number

01223 763873

Email address

mv245@cam.ac.uk

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