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Professor Michele Vendruscolo

Portrait of mv245

 

In the last 15 years our research has been focused on the development of methods of characterising the structure, dynamics and interactions of proteins in previously inaccessible states. These methods are based on the use of experimental data, in particular from nuclear magnetic resonance spectroscopy, as structural restraints in molecular dynamics simulations. Through this approach it is possible to obtain information about a variety of protein conformations, as for example those populated during the folding process, and about protein interactions in complex environments, including those generating aggregate species that are associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

More recently, these studies have led us to investigate the physico-chemical principles of proteins homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. Starting from the observation that proteins are expressed in the cell at levels close to their solubility limits, we are developing approaches to prevent or delay misfolding disorders based on the enhancement of our quality control mechanisms against protein aggregation.

 

 

Publications

Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy.
M Bonomi, R Pellarin, M Vendruscolo
– Biophys J
(2018)
114,
1604
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone
– Biopolymers
(2018)
e23117
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
10,
523
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, A Chiki, A Mittermaier, M Vendruscolo, HA Lashuel, CM Dobson
– Protein Science
(2018)
27,
1262
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annu Rev Phys Chem
(2018)
69,
273
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
306,
57
Principles of Protein Structural Ensemble Determination
M Vendruscolo
– BIOPHYSICAL JOURNAL
(2018)
114,
388A
Fast Fluorescence Lifetime Imaging for Longitudinal Studies of Protein Aggregation in Living C. Elegans
T Sinnige, RF Laine, KY Ma, AJ Haack, P Gaida, N Curry, M Perni, EAA Nollen, CM Dobson, M Vendruscolo, GSK Schierle, CF Kaminski
– BIOPHYSICAL JOURNAL
(2018)
114,
350A
Probing the Interaction of ABETA42 Amyloid Species with an Aggregation Suppressor Molecule by Infrared Nanospectroscopy
FS Ruggeri, J Habchi, S Chia, M Vendruscolo, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2018)
114,
224A
Systematic Development of Small Molecules to Inhibit Specific Steps of alpha-Synuclein Aggregation in Parkinson's Disease
R Staats, P Flagmeier, M Vendruscolo
– BIOPHYSICAL JOURNAL
(2018)
114,
77A
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Research Interest Groups

Telephone number

01223 763873

Email address

mv245@cam.ac.uk