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Yusuf Hamied Department of Chemistry

 

Research Associate

I am a post-doctoral researcher supported by the Schmidt Science Foundation in partnership with the Rhodes Trust and a fellow at St. John's College. My research focusses on developing new experimental and predictive computational methods for examining the behaviour of biological molecules and systems, in particular proteins.

Proteins are the executive molecules of life that through diverse set of highly integrated and tightly regulated interactions set the molecular basis for our well-being. Yet the diverse and dynamic nature of proteins has made it challenging to devise methods that could be effectively used for understanding the roles of proteins in human health and disease. As part of my research, I bring the state-of-the-art micron and nano scale fabrication and flow engineering approaches that I developed during my PhD research together with single molecule optical tools and machine-learning based computational approaches to develop methods for understanding the diversity of the biological roles of proteins. One of my key interests is to develop an explorative probe-free platform for single cell proteomic analysis.

My personal website: http://www.kadiliissaar.com/

Publications

Assessment of fine-tuned large language models for real-world chemistry and material science applications
J Van Herck, MV Gil, KM Jablonka, A Abrudan, AS Anker, M Asgari, B Blaiszik, A Buffo, L Choudhury, C Corminboeuf, H Daglar, AM Elahi, IT Foster, S Garcia, M Garvin, G Godin, LL Good, J Gu, N Xiao Hu, X Jin, T Junkers, S Keskin, TPJ Knowles, R Laplaza, M Lessona, S Majumdar, H Mashhadimoslem, RD McIntosh, SM Moosavi, B Mouriño, F Nerli, C Pevida, N Poudineh, M Rajabi-Kochi, KL Saar, F Hooriabad Saboor, M Sagharichiha, KJ Schmidt, J Shi, E Simone, D Svatunek, M Taddei, I Tetko, D Tolnai, S Vahdatifar, J Whitmer, DCF Wieland, R Willumeit-Römer, A Züttel, B Smit
– Chem Sci
(2024)
16,
670
Single-molecule digital sizing of proteins in solution.
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
– Nat Commun
(2024)
15,
7740
Protein Condensate Atlas from predictive models of heteromolecular condensate composition
KL Saar, RM Scrutton, K Bloznelyte, AS Morgunov, LL Good, AA Lee, SA Teichmann, TPJ Knowles
– Nat Commun
(2024)
15,
5418
Protein Condensate Atlas from predictive models of heteromolecular condensate composition
KL Saar, RM Scrutton, K Bloznelyte, AS Morgunov, LL Good, AA Lee, SA Teichmann, TPJ Knowles
– Nature Communications
(2024)
15,
5418
α-synuclein oligomers displace monomeric α-synuclein from lipid membranes
G Šneiderienė, MA Czekalska, CK Xu, AK Jayaram, G Krainer, WE Arter, QAE Peter, M Castellana-Cruz, KL Saar, A Levin, T Mueller, S Fiedler, SRA Devenish, H Fiegler, JR Kumita, TPJ Knowles
– ACS Nano
(2024)
18,
17469
Biomolecular condensates sustain pH gradients at equilibrium driven by charge neutralisation
H Ausserwöger, R Scrutton, T Sneideris, C Fischer, D Qian, E de Csilléry, K Saar, A Białek, M Oeller, G Krainer, T Franzmann, S Wittmann, J Iglesias-Artola, G Invernizzi, A Hyman, S Alberti, N Lorenzen, T Knowles
(2024)
Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides.
T Sneideris, NA Erkamp, H Ausserwöger, KL Saar, TJ Welsh, D Qian, K Katsuya-Gaviria, MLLY Johncock, G Krainer, A Borodavka, TPJ Knowles
– Nature Communications
(2023)
14,
7170
Single-molecule digital sizing of proteins in solution
G Krainer, RPB Jacquat, M Schneider, T Welsh, J Fan, Q Peter, E Andrzejewska, G Šneiderienė, M Czekalska, H Ausserwoeger, L Chai, W Arter, K Saar, T Herling, T Franzmann, V Kosmoliaptsis, S Alberti, F-U Hartl, S Lee, TPJ Knowles
(2023)
Theoretical and Data-Driven Approaches for Biomolecular Condensates
KL Saar, D Qian, LL Good, AS Morgunov, R Collepardo-Guevara, RB Best, TPJ Knowles
– Chem Rev
(2023)
123,
8988
Turning high-throughput structural biology into predictive inhibitor design
KL Saar, W McCorkindale, D Fearon, M Boby, H Barr, A Ben-Shmuel, COVID Moonshot Consortium, N London, F von Delft, JD Chodera, AA Lee
– Proceedings of the National Academy of Sciences
(2023)
120,
e2214168120
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Research Group

Telephone number

01223 336359

Email address

kls78@cam.ac.uk