skip to content

Department of Chemistry

 

My personal website: http://www.kadiliissaar.com/

I am a post-doctoral researcher supported by the Schmidt Science Foundation in partnership with the Rhodes Trust and a fellow at St. John's College. My research focusses on developing new experimental and predictive computational methods for understanding the behaviour of biological molecules and systems, in particular proteins.

Proteins are the executive molecules of life that through diverse set of highly integrated and tightly regulated interactions set the molecular basis for our well-being. Yet the diverse and dynamic nature of proteins has made it challenging to devise methods that could be effectively used for understanding the roles of proteins in human health and disease. As part of my research, I bring the state-of-the-art micron and nano scale fabrication and flow engineering approaches that I developed during my PhD research together with single molecule optical tools and machine-learning based computational approaches to develop methods for understandind the diversity of the biological roles of proteins. One of my key interests is to develop an explorative probe-free platform for single cell proteomic analysis.

Publications

Multidimensional protein characterisation using microfluidic post-column analysis
T Scheidt, T Kartanas, Q Peter, MM Schneider, KL Saar, T Müller, PK Challa, A Levin, S Devenish, TPJ Knowles
– Lab on a chip
(2020)
20,
2663
Direct digital sensing of proteins in solution through single-molecule optofluidics
G Krainer, K Saar, W Arter, RPB Jacquat, Q Peter, P Challa, C Taylor, D Klenerman, TPJ Knowles
(2020)
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
Rapid two-dimensional characterisation of proteins in solution
KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
– Microsyst Nanoeng
(2019)
5,
33
Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis
MA Wright, FS Ruggeri, KL Saar, PK Challa, JLP Benesch, TPJ Knowles
– Analyst
(2019)
144,
4413
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2019)
58,
6640
Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.
WE Arter, J Charmet, J Kong, KL Saar, TW Herling, T Müller, UF Keyser, TPJ Knowles
– Analytical Chemistry
(2018)
90,
10302
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
306,
57
Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.
KL Saar, T Müller, J Charmet, PK Challa, TPJ Knowles
– Analytical Chemistry
(2018)
90,
8998
Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.
PK Challa, Q Peter, MA Wright, Y Zhang, KL Saar, JA Carozza, JLP Benesch, TPJ Knowles
– Analytical Chemistry
(2018)
90,
3849
  • 1 of 2
  • >

Research Group

Telephone number

01223 336359

Email address

kls78@cam.ac.uk