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Yusuf Hamied Department of Chemistry

 

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.

 

 

 

Selected Publications

 

Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.

Publications

Synthesis, structure, and modeling of a cyclic rhodium(III) porphyrin dimer with an encapsulated 4,4′-bipyridine ligand
H-J Kim, JE Redman, M Nakash, N Feeder, SJ Teat, JKM Sanders
– Inorg Chem
(1999)
38,
5178
Sn(IV) Porphyrins as NMR Shift Reagents and Supramolecular Protecting Groups: Preparation of a Carboxylate−Catenane Porphyrin Complex
Y Tong, DG Hamilton, JC Meillon, JKM Sanders
– Organic Letters
(1999)
1,
1343
STM Images of Individual Porphyrin Molecules on Cu(100) and Cu(111) Surfaces
N Bampos, CN Woodburn, ME Welland, JK Sanders
– Angew Chem Int Ed Engl
(1999)
38,
2780
A general route for the synthesis of flexible porphyrin dimers
LJ Twyman, JKM Sanders
– Tetrahedron Letters
(1999)
40,
6681
Synthesis and post-assembly modification of some functionalised, neutral pi-associated [2]catenanes
Q Zhang, DG Hamilton, N Feeder, SJ Teat, JM Goodman, JKM Sanders
– New Journal of Chemistry
(1999)
23,
897
Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles
GRL Cousins, SA Poulsen, JKM Sanders
– Chemical Communications
(1999)
1575
Assembly of Dynamic Heterometallic Oligoporphyrins Using Cooperative Zinc−Nitrogen, Ruthenium−Nitrogen, and Tin−Oxygen Coordination
HJ Kim, N Bampos, JKM Sanders
– Journal of the American Chemical Society
(1999)
121,
8120
Effects of Shape on Thermodynamic Cyclizations of Cinchona Alkaloids
SJ Rowan, DJ Reynolds, JKM Sanders
– Journal of Organic Chemistry
(1999)
64,
5804
Thin-Film Characterization of Neutral π-Associated Assemblies Incorporating Putative Pseudo-Rotaxanes
DE Lynch, DG Hamilton, NJ Calos, B Wood, JKM Sanders
– Langmuir
(1999)
15,
5600
Ru( II )-centred porphyrin pentamers as coordination building blocks for large porphyrin arrays
CC Mak, N Bampos, JKM Sanders
– Chemical Communications
(1999)
1085
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address

jkms@cam.ac.uk