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Yusuf Hamied Department of Chemistry

 

We are interested in molecular recognition, aiming to uncover and exploit the rules governing non-covalent interactions. Hydrophobic, π–π, donor–acceptor, metal– ligand and hydrogen bonding interactions are used to create new supramolecular systems that expand our understanding of molecular behaviour and may have useful recognition, catalytic or photophysical properties. In particular in the past few years we have developed the concept of dynamic combinatorial chemistry as a new approach for discovering entirely unexpected structures and assemblies. Over the years our building blocks have included peptides, metalloporphyrins, steroids and simple aromatics, and our products have included macrocycles, rotaxanes, catenanes, molecular knots and supramolecular nanotubes. Very recently, while investigating dynamic chemistry in the solid state using ball mill grinding, we have discovered solvent and surface effects on polymorph stability in nanocrystals

Please note that I am not taking any new students or postdocs into my research group.

 

 

 

Selected Publications

 

Evolution of dynamic combinatorial chemistry, Accounts Chem. Res., (2012), 45, 2211.

Discovery of an organic trefoil knot, Science, (2012), 338, 783.

Templated dynamic synthesis of a [3]Catenane, Angew. Chemie Intl. Edn., (2012), 51, 1443.

Thermodynamics of supramolecular naphthalenediimide nanotubes, J. Am. Chem. Soc., (2012), 134, 566.

Discovery of linear receptors for multiple dihydrogen phosphate ions using dynamic combinatorial chemistry, J. Am. Chem. Soc., (2011), 133, 3804.

Formation pathways of Donor-Acceptor catenanes in aqueous dynamic combinatorial libraries, J. Am. Chem. Soc., (2011), 133, 3198.

Solid-state dynamic combinatorial chemistry, Chem. Sci., (2011), 2, 696.

An unexpected receptor for C70, Angew. Chemie Intl. Edn., (2008), 47, 2689.

Publications

Thermodynamically self-assembling porphyrin-stoppered rotaxanes
MJ Gunter, N Bampos, KD Johnstone, JKM Sanders
– New Journal of Chemistry
(2001)
25,
166
A supramolecular array assembled via the complementary binding properties of ruthenium(II) and tin(IV) porphyrins
BG Maiya, N Bampos, AA Kumar, N Feeder, JKM Sanders
– New Journal of Chemistry
(2001)
25,
797
Macrolactone-based dynamic combinatorial libraries of cholate monomers bearing recognition functionality
PS Lukeman, JKM Sanders
– Tetrahedron Letters
(2000)
41,
10171
Synthesis and Recognition Properties of a Ruthenium(II)−Bis(zinc) Cyclic Porphyrin Trimer
SJ Webb, JK Sanders
– Inorg Chem
(2000)
39,
5912
A Tin(IV)−Ruthenium(II)−Tin(IV) Cyclic Porphyrin Trimer with Replaceable Chiral Linings
SJ Webb, JK Sanders
– Inorg Chem
(2000)
39,
5920
Disulfide-strapped porphyrins for monolayer formation on gold.
JE Redman, JK Sanders
– Organic letters
(2000)
2,
4141
Dynamic combinatorial libraries of macrocyclic disulfides in water [35]
S Otto, RLE Furlan, JKM Sanders
– Journal of the American Chemical Society
(2000)
122,
12063
Structure-activity relationships in the acceleration of a hetero Diels-Alder reaction by metalloporphyrin hosts
M Nakash, JK Sanders
– J Org Chem
(2000)
65,
7266
Synthesis under reversible conditions of cyclic porphyrin dimers using palladium-catalysed allyl transesterification
G Kaiser, JKM Sanders
– Chemical Communications
(2000)
1763
Molecular amplification in a dynamic combinatorial library using non-covalent interactions
RLE Furlan, GRL Cousins, JKM Sanders
– Chemical Communications
(2000)
1761
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Research Group

Research Interest Groups

Telephone number

01223 336411

Email address

jkms@cam.ac.uk