Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Autoantibodies against the prion protein in individuals with PRNP mutations.
– Neurology
(2020)
95,
E2028
(doi: 10.1212/wnl.0000000000009183)
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.
– Curr Opin Neurobiol
(2020)
61,
58
(doi: 10.1016/j.conb.2020.01.010)
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid‑β Peptide Aggregation and Reduces the Toxicity of Its Oligomers
– Biomacromolecules
(2020)
21,
1112
(doi: 10.1021/acs.biomac.9b01475)
The catalytic nature of protein aggregation
– The Journal of chemical physics
(2020)
152,
045101
(doi: 10.1063/1.5133635)
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
(2020)
2020.01.08.897488
(doi: 10.1101/2020.01.08.897488)
α-Synuclein strains target distinct brain regions and cell types.
– Nat Neurosci
(2019)
23,
21
(doi: 10.1038/s41593-019-0541-x)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
– Nature communications
(2019)
10,
225
(doi: 10.1038/s41467-018-07699-5)
Dynamics and Control of Peptide Self-Assembly and Aggregation.
– Adv Exp Med Biol
(2019)
1174,
1
(doi: 10.1007/978-981-13-9791-2_1)
Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers
– Biomolecules
(2019)
9,
E659
(doi: 10.3390/biom9110659)
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.
– Commun Biol
(2019)
2,
365
(doi: 10.1038/s42003-019-0612-2)
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