Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
(2021)
2021.07.23.453352
(doi: 10.1101/2021.07.23.453352)
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
– Front Neurosci
(2021)
15,
680026
(doi: 10.3389/fnins.2021.680026)
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.
– Communications Biology
(2021)
4,
613
(doi: 10.1038/s42003-021-02126-w)
Pulsed Hydrogen–Deuterium Exchange Reveals Altered Structures and Mechanisms in the Aggregation of Familial Alzheimer’s Disease Mutants
– ACS Chemical Neuroscience
(2021)
12,
1972
(doi: 10.1021/acschemneuro.1c00072)
Antibody Affinity Governs the Inhibition of SARS-CoV-2 Spike/ACE2 Binding in Patient Serum
– ACS Infect Dis
(2021)
7,
2362
(doi: 10.1021/acsinfecdis.1c00047)
Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation
(2021)
(doi: 10.21203/rs.3.rs-351489/v1)
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
– Nature structural & molecular biology
(2021)
28,
365
(doi: 10.1038/s41594-021-00565-x)
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
– Journal of Chemical Physics
(2021)
154,
125101
(doi: 10.1063/5.0031650)
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans.
– Proceedings of the National Academy of Sciences
(2021)
118,
e2021888118
(doi: 10.1073/pnas.2021888118)
In situ kinetic measurements of α-synuclein aggregation reveal large population of shortlived oligomers
– PLoS One
(2021)
16,
e0245548
(doi: 10.1371/journal.pone.0245548)
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