Research Associate
Education
2016 - PhD in Biophysical Chemistry, University of Cambridge
2011 - MSci in Natural Sciences, Chemistry, UNiversity of Cambridge
2010 - Cambridge-MIT Exchange Program, Massachusetts Institute of Technology
Research Interests
Development and application of fundamental biophysical theories to data analysis in a biologically relevant context, Protein Aggregation, Biophysical Chemistry, High Throughput Screening
Selected Publications
- G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles and D Klenerman "In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease", Science Advances 7, eabh1448 (2021)
- G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Horneman, A Aguzzi, CM Dobson, CJ Sigurdson and TPJ Knowles “Scaling analysis reveals the mechanism and rates of prion replication in vivo”, Nature Structural and Molecular Biology 28, 365 (2021)
- G Meisl, TPJ Knowles, D Klenerman “The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.” Current Opinion in Neurobiology 61, 58 (2020)
- G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Šarić, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson and TPJ Knowles, "Scaling behaviour and rate-determining steps in filamentous self-assembly", Chemcial Science (2017)
- G Meisl, X Yang, CM Dobson, S Linse and TPJ Knowles, "Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants", Chemical Science 8, 4352 (2017)
- G Meisl, JB Kirkegaard, P Arosio, M Vendruscolo, CM Dobson, S Linse and TPJ Knowles, “Molecular mechanisms of protein aggregation from global fitting of kinetic models”, Nature Protocols 11, 252 (2016)
- G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, CM Dobson, S Linse and TPJ Knowles, "Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides.", Proceedings of the National Academy of Sciences, 111, 9384 (2014)
Publications
Extrinsic Amyloid-Binding Dyes for the Detection of Individual Protein Aggregates in Solution
Analytical Chemistry
(2018)
90
10385
(doi: 10.1021/acs.analchem.8b02226)
O3‐01‐05: IN VITRO MEASUREMENTS OF TAU AGGREGATE ELONGATION AND FRAGMENTATION RATES ALLOW THE MODELLING OF PRION‐LIKE SPREADING IN HUMANS
Alzheimer's & Dementia
(2018)
14
p1009
(doi: 10.1016/j.jalz.2018.06.2774)
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
ACS Chemical Biology
(2018)
13
2308
(doi: 10.1021/acschembio.8b00466)
Origin of metastable oligomers and their effects on amyloid fibril self-assembly.
Chemical science
(2018)
9
5937
(doi: 10.1039/c8sc01479e)
On the role of sidechain size and charge in the aggregation of A
Proc Natl Acad Sci U S A
(2018)
115
E5849
(doi: 10.1073/pnas.1803539115)
Kinetic analysis of amyloid formation
Methods Mol Biol
(2018)
1779
181
(doi: 10.1007/978-1-4939-7816-8_12)
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading
ACS chemical neuroscience
(2018)
9
1276
(doi: 10.1021/acschemneuro.8b00094)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation
Annual review of physical chemistry
(2018)
69
1
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions
Analytical Chemistry
(2018)
90
3284
(doi: 10.1021/acs.analchem.7b04820)
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
Chem Commun (Camb)
(2018)
54
7854
(doi: 10.1039/c8cc03002b)
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