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Yusuf Hamied Department of Chemistry

 

Professor Sir Alan Fersht FRS

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

Rapid, electrostatically assisted association of proteins.
G Schreiber, AR Fersht
– Nat Struct Biol
(1996)
3,
427
(doi: 10.1038/nsb0596-427)
Toward a mechanism for GroEL center dot GroES chaperone activity: An ATPase-gated and -pulsed folding and annealing cage
FJ Corrales, AR Fersht
– Proc Natl Acad Sci U S A
(1996)
93,
4509
(doi: 10.1073/pnas.93.9.4509)
Structural and Energetic Responses to Cavity-Creating Mutations in Hydrophobic Cores: Observation of a Buried Water Molecule and the Hydrophilic Nature of Such Hydrophobic Cavities ‡
AM Buckle, P Cramer, AR Fersht
– Biochemistry
(1996)
35,
4298
(doi: 10.1021/bi9524676)
Structure of the transition state for folding of a protein derived from experiment and simulation
V Daggett, A Li, LS Itzhaki, DE Otzen, AR Fersht
– Journal of Molecular Biology
(1996)
257,
430
(doi: 10.1006/jmbi.1996.0173)
Thermodynamics of Transient Conformations in the Folding Pathway of Barnase:  Reorganization of the Folding Intermediate at low pH
M Oliveberg, AR Fersht
– Biochemistry
(1996)
35,
2738
(doi: 10.1021/bi950967t)
Formation of electrostatic interactions on the protein-folding pathway
M Oliveberg, AR Fersht
– Biochemistry
(1996)
35,
2726
(doi: 10.1021/bi9509661)
Catalysis of amide proton exchange by the molecular chaperones GroEL and SecB.
R Zahn, S Perrett, G Stenberg, AR Fersht
– Science
(1996)
271,
642
(doi: 10.1126/science.271.5249.642)
Folding and binding - Editorial overview
KA Dill, AR Fersht
– CURRENT OPINION IN STRUCTURAL BIOLOGY
(1996)
6,
1
(doi: 10.1016/S0959-440X(96)80087-X)
Folding and binding
KA Dill, AR Fersht
– Curr Opin Struct Biol
(1996)
6,
1
(doi: 10.1016/s0959-440x(96)80087-x)
Folding & design: Introduction to a new journal
AR Fersht, FE Cohen
– FOLDING & DESIGN
(1996)
1,
U7
(link to publication)
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