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Yusuf Hamied Department of Chemistry

 

Our major research programme concerns the folding, stability and activity of proteins. We apply a broad multi-disciplinary approach that combines methods and ideas of molecular biology and physical-organic chemistry. We use techniques including protein engineering, DNA cloning, sequencing and mutagenesis, cell culture, gene and peptide synthesis, spectroscopy, rapid reaction techniques, multi-dimensional NMR (we have a 500, 600, 700 and an 800 MHz spectrometers) and x-ray protein crystallography.

Current major projects include: protein folding, misfolding and disease; drug discovery; and structure-activity relationships of proteins involved in cancer and disease.

Although now emeritus, I am still fully active in research with long term funding, including an MRC Programme Grant.

Publications

The Crystal Structure of Human CD1b with a Bound Bacterial Glycolipid
T Batuwangala, D Shepherd, SD Gadola, KJC Gibson, NR Zaccai, AR Fersht, GS Besra, V Cerundolo, EY Jones
– J Immunol
(2004)
172,
2382
Binding of p53-derived Ligands to MDM2 Induces a Variety of Long Range Conformational Changes
O Schon, A Friedler, S Freund, AR Fersht
– J Mol Biol
(2004)
336,
197
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: Implications for "Mutant conformation"
A Friedler, BS DeDecker, SMV Freund, C Blair, S RĂ¼diger, AR Fersht
– J Mol Biol
(2004)
336,
187
Analysis of Enzyme Structure and Activity by Protein Engineering
AR FERSHT, JP SHI, AJ WILKINSON, DM BLOW, P CARTER, MMY WAYE, GP WINTER
– Angewandte Chemie International Edition
(2003)
23,
467
Structural insights in the folding of small single-domain proteins.
S Gianni, U Mayor, AR Fersht
– Ital J Biochem
(2003)
52,
154
The Denatured State of Engrailed Homeodomain under Denaturing and Native Conditions
U Mayor, JG Grossmann, NW Foster, SMV Freund, AR Fersht
– Journal of molecular biology
(2003)
333,
977
Unifying features in protein-folding mechanisms
S Gianni, NR Guydosh, F Khan, TD Caldas, U Mayor, GWN White, ML DeMarco, V Daggett, AR Fersht
– Proceedings of the National Academy of Sciences
(2003)
100,
13286
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
N Issaeva, A Friedler, P Bozko, KG Wiman, AR Fersht, G Selivanova
– Proceedings of the National Academy of Sciences of the United States of America
(2003)
100,
13303
The kinetic pathway of folding of barnase.
F Khan, JI Chuang, S Gianni, AR Fersht
– J Mol Biol
(2003)
333,
169
Crystal structure of a superstable mutant of human p53 core domain - Insights into the mechanism of rescuing oncogenic mutations
AC Joerger, MD Allen, AR Fersht
– J Biol Chem
(2003)
279,
1291
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