My research focuses on developing a theoretical framework to explain pathological data in neurodegenerative diseases, including progressive supranuclear palsy and Alzheimer's disease, by studying their underlying molecular mechanisms. I obtained my bachelor's degree in Physics from National Taiwan University, where I optimized optical microscopy to its theoretical limit for my undergraduate project, sparking my interest in applying theoretical frameworks to biological systems. In my free time, I enjoy hiking, cooking, and have climbed over ten 3000m+ mountains in Taiwan.
Publications
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
– Advanced Science
(2025)
e11297
(doi: 10.1002/advs.202511297)
BPS2025 - A mathematical model to quantify tau aggregation rates and determine molecular mechanisms from patient data
– Biophysical Journal
(2025)
124,
408a
(doi: 10.1016/j.bpj.2024.11.2197)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
(2024)
(doi: 10.1101/2024.12.14.24318991)
Optical volumetric brain imaging: speed, depth, and resolution enhancement
– Journal of Physics D
(2021)
54,
323002
(doi: 10.1088/1361-6463/abff7b)